Screening of novel chemical compounds as possible inhibitors of carbonic anhydrase and photosynthetic activity of photosystem II       
Mehmet Sayım Karacan
Gazi Üniversitesi, Türkiye
Mamaş Serhat
Zharmukhamedov Sergei
Elena Kupriyanova
Alexandr Shitov
Vyacheslav Klimov
Prof. Dr. Neslihan ÖZBEK
Ahi Evran Üniversitesi, Türkiye
Ümmühan Özdemir Özmen
Gazi Üniversitesi, Türkiye
Ayla Balaban Gündüzalp
Gazi Üniversitesi, Türkiye
Franz Josef Schmitt
Nurcan Karacan
Gazi Üniversitesi, Türkiye
Thomas Friedrich
Dmitry Los
Robert Carpentier
Suleyman Allakhverdiev
Thirty novel chemical compounds were designed and synthesized expecting that they would be possible inhibitors. From this number eleven were organic bases, twenty-four were their organic derivatives and fourteen were metal complexes. Screening of these chemicals by their action on photosynthetic electron transfer (PET) and carbonic anhydrase (CA) activity (CAA) of photosystem II (PSII), α-CA, as well as β-CA was done. Several groups were revealed among them. Some of them are capable to suppress either one, two, three, or even all of the measured activities. As example, one of the Cu(II)-phenyl sulfonylhydrazone complexes (compound 25) suppresses CAA of α-CA by 88%, CAA of β-CA by 100% inhibition; CAA of PSII by 100% and the PSII photosynthetic activity by 66.2%. The Schiff base compounds (12, 15) and Cu(II)-phenyl sulfonylhydrazone complexes (25, 26) inhibited the CAA and PET of PSII significantly. The obtained data indicate that the PSII donor side is a target of the inhibitory action of these agents. Some physico- or electrochemical properties such as diffusion coefficient, number of transferred electrons, peak potential and heterogeneous standard rate constants of the compounds were determined in nonaqueous media. pKa values were also determined in nonaqueous and aqueous media. Availability in the studied group of novel chemical agents possessing different inhibitory activity allow in future to isolate the "active part" in the structure of the inhibitors responsible for different inhibitory mechanisms, as well as to determine the influence of side substituters on its inhibitory efficiency. © 2013 Elsevier B.V. All rights reserved.
Anahtar Kelimeler
Carbonic anhydrase | Carbonic anhydrase inhibitors | New inhibitors | Photosynthetic inhibitors | Photosystem II
Makale Türü Özgün Makale
Makale Alt Türü SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale
Dergi Adı Journal of Photochemistry and Photobiology B: Biology
Dergi ISSN 1011-1344
Dergi Tarandığı Indeksler SCI
Makale Dili İngilizce
Basım Tarihi 08-2014
Cilt No 137
Sayfalar 156 / 167
Doi Numarası 10.1016/j.jphotobiol.2013.12.002
Makale Linki