| Yazarlar |
Ayla Balaban Gündüzalp
Gazi Üniversitesi, Türkiye |
|
Gökhan Parlakgümüş
|
|
Demet Uzun
Gazi Üniversitesi, Türkiye |
|
Ümmühan Özdemir Özmen
Gazi Üniversitesi, Türkiye |
Prof. Dr. Neslihan ÖZBEK
Ahi Evran Üniversitesi, Türkiye |
|
Musa Sarı
Gazi Üniversitesi, Türkiye |
|
Tuncay Tunç
Aksaray Üniversitesi, Türkiye |
| Özet |
| The methane sulfonic acide hydrazide (1) was used to obtain furan sulfonylhydrazones; 2-acetylfuranmethanesulfonylhydrazone (2), 2-furaldehydemethanesulfonylhydrazone (3), 5-nitro-2-furaldehydemethanesulfonylhydrazone (4). The structures of furan sulfonylhydrazones were determined by using elemental analysis, FT-IR, 1H NMR, 13C NMR and UV-vis methods. The structure of 5-nitro-2-furaldehydemethanesulfonylhydrazone (4) was also supported with X-ray difraction method and found that compound 4 was crystallized in triclinic, space group P1¯. In order to gain insight into the structure of the compounds, we performed computational studies by using 6-311G(d,p) basic set in which B3LYP correlation function was implemented. The geometry of the sulfonylhydrazones were optimized at DFT method with Gaussian 09 program package and the global reactivity descriptors were also calculated by this basic set. The enzyme inhibition activities of the sulfonylhydrazones were investigated on carbonic anhydrase I (hCA I) isoenzyme and their activity parameters (Km, IC50 and Ki) were calculated by spectrophotometric method. And also, their inhibitor effects were also investigated by cyclic voltammetry (CV) and differential pulse voltammetry (DPV) methods. Inhibition results show that compound 4 containing electron withdrawing group (NO2) has higher inhibition effect on hCA I isoenzyme than other's. |
| Anahtar Kelimeler |
| Carbonic anhydrase I (hCA I) | Cyclic voltammetry (CV) | Differantial pulse voltammetry (DPV) | Enzyme inhibition | Furan sulfonylhydrazone |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | JOURNAL OF MOLECULAR STRUCTURE |
| Dergi ISSN | 0022-2860 |
| Dergi Tarandığı Indeksler | SCI |
| Makale Dili | İngilizce |
| Basım Tarihi | 02-2016 |
| Cilt No | 1105 |
| Sayı | 1 |
| Sayfalar | 332 / 340 |
| Doi Numarası | 10.1016/j.molstruc.2015.10.054 |
| Makale Linki | http://linkinghub.elsevier.com/retrieve/pii/S0022286015303562 |
| Atıf Sayıları | |
| WoS | 22 |
| SCOPUS | 19 |
| Google Scholar | 28 |
