Carbonic anhydrase inhibitors Synthesis characterization and inhibition activities of furan sulfonylhydrazones against carbonic anhydrase I hCA I
Yazarlar (7)
Ayla Balaban Gündüzalp Gazi Üniversitesi, Türkiye
Gökhan Parlakgümüş Gazi Üniversitesi, Türkiye
Demet Uzun Gazi Üniversitesi, Türkiye
Ümmühan Özdemir Özmen Gazi Üniversitesi, Türkiye
Prof. Dr. Neslihan ÖZBEK Kırşehir Ahi Evran Üniversitesi, Türkiye
Musa Sarı Gazi Üniversitesi, Türkiye
Tuncay Tunç Aksaray Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Journal of Molecular Structure | ||
| Dergi ISSN | 0022-2860 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 02-2016 |
| Kabul Tarihi | 12-04-2026 | Yayınlanma Tarihi | – |
| Cilt / Sayı / Sayfa | 1105 / 1 / 332–340 | DOI | 10.1016/j.molstruc.2015.10.054 |
| Makale Linki | http://linkinghub.elsevier.com/retrieve/pii/S0022286015303562 | ||
| Özet |
| The methane sulfonic acide hydrazide (1) was used to obtain furan sulfonylhydrazones; 2-acetylfuranmethanesulfonylhydrazone (2), 2-furaldehydemethanesulfonylhydrazone (3), 5-nitro-2-furaldehydemethanesulfonylhydrazone (4). The structures of furan sulfonylhydrazones were determined by using elemental analysis, FT-IR, 1 H NMR, 13 C NMR and UV–vis methods. The structure of 5-nitro-2-furaldehydemethanesulfonylhydrazone (4) was also supported with X-ray difraction method and found that compound 4 was crystallized in triclinic, space group P 1¯. In order to gain insight into the structure of the compounds, we performed computational studies by using 6–311G (d, p) basic set in which B3LYP correlation function was implemented. The geometry of the sulfonylhydrazones were optimized at DFT method with Gaussian 09 program package and the global reactivity descriptors were also calculated by this … |
| Anahtar Kelimeler |
| Carbonic anhydrase I (hCA I) | Cyclic voltammetry (CV) | Differantial pulse voltammetry (DPV) | Enzyme inhibition | Furan sulfonylhydrazone |
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Carbonic anhydrase inhibitors Synthesis characterization and inhibition activities of furan sulfonylhydrazones against carbonic anhydrase I hCA I
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 32 |
| Scopus | 6 |
| Web of Science | 25 |