Characterization antibacterial anticarbonic anhydrase II isoenzyme anticancer electrochemical and computational studies of sulfonic acid hydrazide derivative and its Cu II complex      
Ümmühan Özdemir Özmen
Gazi Üniversitesi, Türkiye
Ebru Aktan
Gazi Üniversitesi, Türkiye
İlbiz Firdevs
Ayla Balaban Gündüzalp
Gazi Üniversitesi, Türkiye
Prof. Dr. Neslihan ÖZBEK
Ahi Evran Üniversitesi, Türkiye
Musa Sarı
Gazi Üniversitesi, Türkiye
Ömer Çelik
Dicle Üniversitesi, Türkiye
Sinan Saydam
Fırat Üniversitesi, Türkiye
A new N′-acetyl butane sulfonic acid hydrazide, C4H9-SO2-NH-NH-COCH3 (Absh, an sulfonamide compound), and its Cu(II) complex [Cu(Absh)2(CH3COO)2], have been synthesized and characterized by elemental analysis, spectrometric methods (1H-13C NMR, FT-IR, LC-MS), thermal analysis, magnetic susceptibility and conductivity measurements. In addition, molecular structure of the ligand, Absh was determined by single crystal X-ray diffraction technique and found that the compound crystallizes in monoclinic, space group P21/c. To gain information about the structure of the ligand and its complex, we have performed computational studies using density functional theory (DFT) for optimized geometries of the compounds. Electrochemical studies showed that, the complex is electrochemically active and has one irreversible reduction and one irreversible oxidation potentials, and the half wave reduction potentials are -1.15 and 0.45 volt respectively, versus ferrocene/ferrocenium internal reference electrode. The antibacterial activities of synthesized compounds were studied against Gram positive bacteria; Staphylococcus aureus ATCC 6538, Bacillus subtilis ATCC 6633, Bacillus cereus NRRL-B-3711, Enterococcus faecalis ATCC 29212 and Gram negative bacteria; Escherichia coli ATCC 11230, Pseudomonas aeruginosa ATCC 15442, Klebsiella pneumonia ATCC 70063 by using the disc diffusion and micro dilution methods. The inhibition activities of these compounds on carbonic anhydrase II enzyme (hCA II) have been investigated by comparing IC50 and Ki values. The anticancer activities of these compounds on MCF-7 cell line investigated by comparing IC50 values. The biological activity screening showed that Cu(II) complex has more activity than ligand against the tested bacteria, hCA II enzyme and breast cancer cell lines MCF-7.
Anahtar Kelimeler
Biological activities | Butane sulfonic acid hydrazide | Crystal structure | Cu(II) complex | DFT | Electrochemical studies
Makale Türü Özgün Makale
Makale Alt Türü SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale
Dergi Adı Inorganica Chimica Acta
Dergi ISSN 0020-1693
Dergi Tarandığı Indeksler SCI
Makale Dili İngilizce
Basım Tarihi 11-2014
Cilt No 423
Sayfalar 194 / 203
Doi Numarası 10.1016/j.ica.2014.09.033
Makale Linki