Synthesis characterization and anti microbial evaluation of Cu II Ni II Pt II and Pd II sulfonylhydrazone complexes 2D QSAR analysis of Ni II complexes of sulfonylhydrazone derivatives       
Prof. Dr. Neslihan ÖZBEK
Ahi Evran Üniversitesi, Türkiye
Saliha Alyar
Hamit Alyar
Çankırı Karatekin Üniversitesi, Türkiye
Ertan Şahin
Atatürk Üniversitesi, Türkiye
Nurcan Karacan
Gazi Üniversitesi, Türkiye
Copper(II), nickel(II), platinum(II) and palladium(II) complexes with 2-hydroxy-1-naphthaldehyde-N-methylpropanesulfonylhydrazone (nafpsmh) derived from propanesulfonic acid-1-methylhydrazide (psmh) were synthesized, their structure were identified, and antimicrobial activity of the compounds was screened against three Gram-positive and three Gram-negative bacteria. The results of antimicrobial studies indicate that Pt(II) and Pd(II) complexes showed the most activity against all bacteria. The crystal structure of 2-hydroxy-1-naphthaldehyde-N-methylpropanesulfonylhydrazone (nafpsmh) was also investigated by X-ray analysis. A series of Ni(II) sulfonyl hydrazone complexes (1-33) was synthesized and tested in vitro against Escherichia coli and Staphylococcus aureus. Their antimicrobial activities were used in the QSAR analysis. Four-parameter QSAR models revealed that nucleophilic reaction index for Ni and O atoms, and HOMO-LUMO energy gap play key roles in the antimicrobial activity. © 2013 Elsevier B.V. All rights reserved.
Anahtar Kelimeler
2D-QSAR | Antimicrobial activity | Ni(II) sulfonyl hydrazone derivatives | Sulfonylhydrazide | Sulfonylhydrazone | X-ray structure
Makale Türü Özgün Makale
Makale Alt Türü SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale
Dergi Adı Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
Dergi ISSN 1386-1425
Dergi Tarandığı Indeksler SCI
Makale Dili İngilizce
Basım Tarihi 05-2013
Cilt No 108
Sayfalar 123 / 132
Doi Numarası 10.1016/j.saa.2013.01.005
Makale Linki