| Yazarlar |
Neslihan ÖZBEK
Ahi Evran Üniversitesi, Türkiye |
Saliha Alyar
|
|
Hamit Alyar
Çankırı Karatekin Üniversitesi, Türkiye |
|
Ertan Şahin
Atatürk Üniversitesi, Türkiye |
|
Nurcan Karacan
Gazi Üniversitesi, Türkiye |
| Özet |
| Copper(II), nickel(II), platinum(II) and palladium(II) complexes with 2-hydroxy-1-naphthaldehyde-N-methylpropanesulfonylhydrazone (nafpsmh) derived from propanesulfonic acid-1-methylhydrazide (psmh) were synthesized, their structure were identified, and antimicrobial activity of the compounds was screened against three Gram-positive and three Gram-negative bacteria. The results of antimicrobial studies indicate that Pt(II) and Pd(II) complexes showed the most activity against all bacteria. The crystal structure of 2-hydroxy-1-naphthaldehyde-N-methylpropanesulfonylhydrazone (nafpsmh) was also investigated by X-ray analysis. A series of Ni(II) sulfonyl hydrazone complexes (1-33) was synthesized and tested in vitro against Escherichia coli and Staphylococcus aureus. Their antimicrobial activities were used in the QSAR analysis. Four-parameter QSAR models revealed that nucleophilic reaction index for Ni and O atoms, and HOMO-LUMO energy gap play key roles in the antimicrobial activity. © 2013 Elsevier B.V. All rights reserved. |
| Anahtar Kelimeler |
| 2D-QSAR | Antimicrobial activity | Ni(II) sulfonyl hydrazone derivatives | Sulfonylhydrazide | Sulfonylhydrazone | X-ray structure |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY |
| Dergi ISSN | 1386-1425 |
| Dergi Tarandığı Indeksler | SCI |
| Makale Dili | İngilizce |
| Basım Tarihi | 05-2013 |
| Cilt No | 108 |
| Sayı | 1 |
| Sayfalar | 123 / 132 |
| Doi Numarası | 10.1016/j.saa.2013.01.005 |
| Makale Linki | http://linkinghub.elsevier.com/retrieve/pii/S1386142513000310 |
| Atıf Sayıları | |
| WoS | 36 |
| SCOPUS | 39 |
| Google Scholar | 47 |
