Experimental and theoretical studies on methanesulfonic acid 1 methylhydrazide Antimicrobial activities of its sulfonyl hydrazone derivatives      
Prof. Dr. Neslihan ÖZBEK
Ahi Evran Üniversitesi, Türkiye
Alyar Saliha
Nurcan Karacan
Gazi Üniversitesi, Türkiye
Methanesulfonic acid 1-methylhydrazide (msmh) and its sulfonyl hydrazone derivatives, salicylaldehyde-N-methylmethanesulfonylhydrazone (salmsmh) and 2-hydroxy-1-naphthaldehyde-N-methylmethanesulfonylhydrazone (nafmsmh) were synthesized and characterized by using FT-IR, 1H NMR, 13C NMR, LC-MS and elemental analysis. Conformation analysis of msmh based on DFT/B3LYP/6-311G(d) method was performed. 1H and 13C shielding tensors of msmh for the most stable conformer were calculated with GIAO/DFT/B3LYP/6-311++G(2d, 2p) methods in vacuo and various solvents such as DMSO, THF, acetonitrile, methanol and aqueous solution. The harmonic vibrational wavenumbers for the most stable conformer were calculated using at B3LYP/6-311G(d) level. Antimicrobial activity of the compounds was also screened against Gram-positive bacteria (Staphylococcus aureus ATCC 25923, Bacillus cereus RSKK 863) and Gram-negative bacteria (Escherichia coli ATCC 11230, Salmonella enterititis ATCC 40376, Pseudomonos aeruginosa ATCC 28753) by both disc diffusion and micro dilution methods. © 2009 Elsevier B.V. All rights reserved.
Anahtar Kelimeler
Antimicrobial activity | DFT | NMR spectra | Sulfonyl hydrazide | Sulfonyl hydrazone
Makale Türü Özgün Makale
Makale Alt Türü SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale
Dergi Adı Journal of Molecular Structure
Dergi ISSN 0022-2860
Dergi Tarandığı Indeksler SCI
Makale Dili İngilizce
Basım Tarihi 12-2009
Cilt No 938
Sayı 1
Sayfalar 48 / 53
Doi Numarası 10.1016/j.molstruc.2009.09.002
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