Synthesis crystal structure antibacterial activities and electrochemical studies of new N N polymethylene bis sulfonamides      
Prof. Dr. Neslihan ÖZBEK
Ahi Evran Üniversitesi, Türkiye
Alyar Saliha
Mamaş Serhat
Ertan Şahin
Atatürk Üniversitesi, Türkiye
Nurcan Karacan
Gazi Üniversitesi, Türkiye
Four disulfonamide derivatives (C 2H 5·SO 2·NH) 2(CH 2) n (n = 2, 3, 4, 5) were synthesized and characterized by FTIR, 1H NMR, 13C NMR, HETCOR, LCMS and elemental analysis. Ethanesulfonamide-N,N′- pentamethylene bis was also characterized by X-ray single crystal diffraction measurement. The electrochemical characteristics of the disulfonamide derivatives were performed by cyclic voltammetry and chronoamperometry. 1H and 13C NMR chemical shifts of the compounds were calculated by using DFT/B3LYP methods with a 6-311++G (d,p) basis set. Antibacterial activity and the structural relationship of the compounds showed that activity decreases proportionately to the increasing length of the carbon chain between NH groups, log P values, hydration energy and molecular volumes. Anodic peak potentials and HOMO values do not correlate with the activity, but reduction potential and LUMO decrease weakly with increasing activity. © 2011 Elsevier B.V. All rights reserved.
Anahtar Kelimeler
Antimicrobial activity | Bis-sulfonamides | Cyclic voltammetry | X-ray structure
Makale Türü Özgün Makale
Makale Alt Türü SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale
Dergi Adı Journal of Molecular Structure
Dergi ISSN 0022-2860
Dergi Tarandığı Indeksler SCI
Makale Dili İngilizce
Basım Tarihi 02-2012
Cilt No 1010
Sayfalar 1 / 7
Doi Numarası 10.1016/j.molstruc.2011.10.040
Makale Linki