Alkyl sulfonic acide hydrazides Synthesis characterization computational studies and anticancer antibacterial anticarbonic anhydrase II hCA II activities

Ozdemir, Ummuhan O.; Ilbiz, Firdevs; Gunduzalp, Ayla Balaban; ÖZBEK, NESLİHAN; Genç, Zuhal Karagoz; Hamurcu, Fatma; Tekin, Suat

doi:10.1016/j.molstruc.2015.07.054

Alkyl sulfonic acide hydrazides Synthesis characterization computational studies and anticancer antibacterial anticarbonic anhydrase II hCA II activities

Yazarlar (7)

Ummuhan O. Ozdemir
Gazi Üniversitesi, Türkiye

Firdevs Ilbiz
Gazi Üniversitesi, Türkiye

Ayla Balaban Gunduzalp
Gazi Üniversitesi, Türkiye

Prof. Dr. Neslihan ÖZBEK Kırşehir Ahi Evran Üniversitesi, Türkiye

Zuhal Karagoz Genç
Adiyaman Üniversitesi, Türkiye

Fatma Hamurcu
Bartin Üniversitesi, Türkiye

Suat Tekin
Inönü Üniversitesi, Türkiye

Makale Türü	Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
Dergi Adı	Journal of Molecular Structure
Dergi ISSN	0022-2860 Wos Dergi Scopus Dergi
Dergi Tarandığı Indeksler	SCI
Makale Dili	İngilizce	Basım Tarihi	11-2015
Cilt / Sayı / Sayfa	1100 / 1 / 464–474	DOI	10.1016/j.molstruc.2015.07.054
Makale Linki	http://linkinghub.elsevier.com/retrieve/pii/S0022286015301654

Özet

Abstract Methane sulfonic acide hydrazide, CH3SO2NHNH2 (1), ethane sulfonic acide hydrazide, CH3CH2SO2NHNH2 (2), propane sulfonic acide hydrazide, CH3CH2CH2SO2NHNH2 (3) and butane sulfonic acide hydrazide, CH3CH2CH2CH2SO2NHNH2 (4) have been synthesized as homologous series and characterized by using elemental analysis, spectrophotometric methods (¹H-¹³C NMR, FT-IR, LC-MS). In order to gain insight into the structure of the compounds, we have performed computational studies by using 6-311G(d, p) functional in which B3LYP functional were implemented. The geometry of the sulfonic acide hydrazides were optimized at the DFT method with Gaussian 09 program package. A conformational analysis of compounds were performed by using NMR theoretical calculations with DFT/B3LYP/6-311++G(2d, 2p) level of theory by applying the (GIAO) approach. The anticancer activities of these compounds on MCF-7 human breast cancer cell line investigated by comparing IC50 values. The antibacterial activities of synthesized compounds were studied against Gram positive bacteria; Staphylococcus aureus ATCC 6538, Bacillus subtilis ATCC 6633, Bacillus cereus NRRL-B-3711, Enterococcus faecalis ATCC 29212 and Gram negative bacteria; Escherichia coli ATCC 11230, Pseudomonas aeruginosa ATCC 15442, Klebsiella pneumonia ATCC 70063 by using the disc diffusion method. The inhibition activities of these compounds on carbonic anhydrase II enzyme (hCA II) have been investigated by comparing IC50 and Ki values. The biological activity screening shows that butane sulfonic acide hydrazide (4) has more activity than the others against tested breast cancer cell lines MCF-7, Gram negative/Gram positive bacteria and carbonic anhydrase II (hCA II) isoenzyme.

Anahtar Kelimeler

Science Direct

BM Sürdürülebilir Kalkınma Amaçları

Atıf Sayıları
WoS	31
SCOPUS	33
Google Scholar	39

Alkyl sulfonic acide hydrazides Synthesis characterization computational studies and anticancer antibacterial anticarbonic anhydrase II hCA II activities

Dergi Adı	Journal of Molecular Structure
Yayıncı	Elsevier B.V.
Açık Erişim	Hayır
ISSN	0022-2860
E-ISSN	1872-8014
CiteScore	8,0
SJR	0,628
SNIP	0,999

Alkyl sulfonic acide hydrazides Synthesis characterization computational studies and anticancer antibacterial anticarbonic anhydrase II hCA II activities

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