Synthesis characterization and crystal structures of new Zinc II and Nickel II complexes containing morpholine moiety and their antibacterial studies      
Hamid Goudarziafshar
Majid Rezaeivala
Khosravı Fayezeh
Younes Abbasityule
Somaieh Yousefi
Prof. Dr. Neslihan ÖZBEK
Ahi Evran Üniversitesi, Türkiye
Vaclav Eigner
Mıchal Dusek
The ligand 1,2-dimorpholinoethane (DME) was used to prepare Zn(II) and Ni(II) complexes of the general formulation MLX2 (L = DME, X = Cl or NO3). Zinc(II) complex exhibits spectral properties indicative of a distorted tetrahedral geometry, with DME coordinating through two nitrogen atoms and two chlorides completing the tetrahedron. This is in contrast to the six-coordinated, distorted octahedral geometry exhibited by nickel(II) complex of DME when NO3 was used as counter ions. The X-ray diffraction confirms the structures of two complexes and shows that the ligand coordinates through two nitrogen atoms while the two ether linkages are not involved in complexation, which would have been the case if the morpholine rings were in the boat form. The ligand and related complexes have antibacterial activity against the five Gram-positive bacteria: Bacillus subtilis ATCC 6633, Staphylococcus aureus ATCC 6538, Bacillus cereus NRRL-B-3711, Enterococcus faecalis ATCC 29212 and Streptococcus pyogenes and also against the three Gram-negative bacteria: Escherichia coli ATCC 11230, Pseudomonas aeruginosa ATCC 15442 and Klebsiella pneumonia ATCC 70063. The results showed that in some cases the antibacterial activity of the complexes exceeded the one of sulfisoxazole used as a standard.
Anahtar Kelimeler
Antibacterial effects | Crystal structure | Morpholine moiety | Nickel(II) complex | Zinc(II) complex
Makale Türü Özgün Makale
Makale Alt Türü SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale
Dergi Adı Journal of the Iranian Chemical Society
Dergi ISSN 1735-207X
Dergi Tarandığı Indeksler SCI
Makale Dili İngilizce
Basım Tarihi 01-2015
Cilt No 12
Sayı 1
Sayfalar 113 / 119
Doi Numarası 10.1007/s13738-014-0462-2
Makale Linki