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Synthesis characterization and antimicrobial activity of new aliphatic sulfonamide       
Yazarlar
Prof. Dr. Neslihan ÖZBEK
Ahi Evran Üniversitesi, Türkiye
Katırcıoğlu Türk Hikmet
Nurcan Karacan
Gazi Üniversitesi, Türkiye
Baykal Tülay
Özet
A series of novel aliphatic sulfonamide derivatives (1-7) were synthesized and characterized by elemental analyses, FT-IR, 1H NMR, 13C NMR and LC-MS techniques. All the synthesized compounds were evaluated in vitro as antimicrobial agents against representative strains of Gram-positive (Staphylococcus aureus ATCC 25953, Bacillus cereus ATCC 6633 and Listeria monocytogenes ATCC Li6 (isolate), Gram-negative bacteria (Escherichia coli ATCC 11230) and antifungal agent against Candida albicans (clinical isolate) by both disc diffusion and minimal inhibition concentration (MIC) methods. All these bacteria and fungus studied were screened against some antibiotics to compare with our chemicals' zone diameters. Our aliphatic sulfonamides have highest powerful antibacterial activity for Gram-negative bacteria than Gram-positive bacteria and antibacterial activity decreases as the length of the carbon chain increases.
Anahtar Kelimeler
Aliphatic sulfonamide | Antimicrobial activity | MIC | Sulfonamides
Makale Türü Özgün Makale
Makale Alt Türü SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale
Dergi Adı Bioorganic Medicinal Chemistry
Dergi ISSN 0968-0896
Dergi Tarandığı Indeksler SCI
Makale Dili İngilizce
Basım Tarihi 08-2007
Cilt No 15
Sayı 15
Sayfalar 5105 / 5109
Doi Numarası 10.1016/j.bmc.2007.05.037
Makale Linki http://linkinghub.elsevier.com/retrieve/pii/S096808960700452X
BM Sürdürülebilir Kalkınma Amaçları
Atıf Sayıları
WoS 138
SCOPUS 148
Google Scholar 197
ResearchGate 162
Synthesis characterization and antimicrobial activity of new aliphatic sulfonamide

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