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Three New Copper (II) Complexes with CHIRAL SCHIFF BASES: Synthesis, Characterization, DNA Binding and DNA-Cleavage Studies    
Yazarlar
Doç. Dr. Turgay TUNÇ Doç. Dr. Turgay TUNÇ
Kırşehir Ahi Evran Üniversitesi, Türkiye
Prof. Dr. Nadir DEMİREL Prof. Dr. Nadir DEMİREL
Kırşehir Ahi Evran Üniversitesi, Türkiye
Mahmut Emir
Prof. Dr. Aslıhan GÜNEL Prof. Dr. Aslıhan GÜNEL
Kırşehir Ahi Evran Üniversitesi, Türkiye
Rıfkı Kadıoğlu
Kırşehir Ahi Evran Üniversitesi, Türkiye
Nurcan Karacan
Gazi Üniversitesi, Türkiye
Özet
Summary: New mononuclear copper (II) complexes (1, 2 and 3) were synthesized from Schiff bases (H2L) of chiral amino alcohols. The structures of the copper complexes were proposed by a combination of elemental analyses, FTIR, LCMS, magnetic susceptibility and molar conductance measurement methods. Spectroscopic and analytical data of the complexes suggest four-coordinated structures. Geometry optimization carried out with DFT/6-31G (d,p) were proposed to be distorted square planar geometry for the complexes. The similarity between experimental and theoretical IR spectra confirms the proposed structures. The interaction of copper (II) complexes with calf thymus (CT-DNA) was investigated using absorption titration method. The results suggest that the complex 1 and 2 can bind to DNA by intercalation. Binding constants Kb were found to be 2.46×10 5 for 1, 5.41×10 5 for 2 and 7.00×10 4 for 3. Moreover, agarose gel electrophoresis assay demonstrates that all complexes were found to cleavage of plasmid pentry/d-topo plasmid DNA. Complex 2 shows the best cleavage activity (5 µM).
Anahtar Kelimeler
Copper (II) complexes | DFT | DNA binding | DNA cleavage | Schiff base complexes
Makale Türü Özgün Makale
Makale Alt Türü SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale
Dergi Adı J.Chem.Soc.Pak
Dergi ISSN 0253-5106
Dergi Tarandığı Indeksler SCI-Expanded
Dergi Grubu Q4
Makale Dili İngilizce
Basım Tarihi 01-2019
Cilt No 41
Sayı 2
Sayfalar 334 / 344
BM Sürdürülebilir Kalkınma Amaçları
Atıf Sayıları
SCOPUS 1
Google Scholar 1

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