DNA Binding and Cleavage Activity of Three New Copper (II) Complexes of Chiral N-Salicyl-β-Amino Alcohol Schiff Bases
Yazarlar (6)
Doç. Dr. Turgay TUNÇ
Kırşehir Ahi Evran Üniversitesi, Türkiye
Prof. Dr. Nadir DEMİREL
Kırşehir Ahi Evran Üniversitesi, Türkiye
Kırşehir Ahi Evran Üniversitesi, Türkiye
Prof. Dr. Aslıhan GÜNEL
Kırşehir Ahi Evran Üniversitesi, Türkiye
Dicle Üniversitesi, Türkiye
Gazi Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Journal of the Mexican Chemical Society (Q4) | ||
| Dergi ISSN | 1870-249X Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 04-2018 |
| Cilt / Sayı / Sayfa | 62 / 3 / 51–66 | DOI | 10.29356/jmcs.v62i3.424 |
| Makale Linki | https://www.jmcs.org.mx/index.php/jmcs/article/view/424 | ||
| Özet |
| Three new copper(II) complexes (1-3) with general formula [Cu(HL)CH 3 COO] of N-salicyl-β-amino alcohol Schiff bases containing, (S)-(+)-phenyl glycinol, (1S, 2R)-2-amino-1, 2-diphenylethanol and 1, 1, 3-triphenyl-(R)-(+)-2-amino propanol, were synthesized. Their structures were characterized by FTIR, LCMS, magnetic moment, molar conductance and elemental analysis data. DFT calculations proposed distorted square planar geometries for the complexes. The calculated IR spectra are in good agreement with the experimental IR spectra, confirming the proposed structures. Their interactions with calf thymus DNA were investigated and their binding constants K b were found. Gel electrophoresis reveals that all complexes display significant nuclease activity against supercoiled pentry/d-topo plasmid DNA. |
| Anahtar Kelimeler |
| Copper (II) complexes | DFT calculations | DNA binding | DNA cleavage | Schiff base complexes |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 2 |
| SCOPUS | 3 |
| Google Scholar | 3 |