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DNA Binding and Cleavage Activity of Three New Copper (II) Complexes of Chiral N-Salicyl-β-Amino Alcohol Schiff Bases    
Yazarlar
Doç. Dr. Turgay TUNÇ Doç. Dr. Turgay TUNÇ
Kırşehir Ahi Evran Üniversitesi, Türkiye
Prof. Dr. Nadir DEMİREL Prof. Dr. Nadir DEMİREL
Kırşehir Ahi Evran Üniversitesi, Türkiye
Mahmut Emir
Prof. Dr. Aslıhan GÜNEL Prof. Dr. Aslıhan GÜNEL
Kırşehir Ahi Evran Üniversitesi, Türkiye
Mehmet Çolak
Dicle Üniversitesi, Türkiye
Nurcan Karacan
Gazi Üniversitesi, Türkiye
Özet
Three new copper(II) complexes (1-3) with general formula [Cu(HL)CH 3 COO] of N-salicyl-β-amino alcohol Schiff bases containing, (S)-(+)-phenyl glycinol, (1S, 2R)-2-amino-1, 2-diphenylethanol and 1, 1, 3-triphenyl-(R)-(+)-2-amino propanol, were synthesized. Their structures were characterized by FTIR, LCMS, magnetic moment, molar conductance and elemental analysis data. DFT calculations proposed distorted square planar geometries for the complexes. The calculated IR spectra are in good agreement with the experimental IR spectra, confirming the proposed structures. Their interactions with calf thymus DNA were investigated and their binding constants K b were found. Gel electrophoresis reveals that all complexes display significant nuclease activity against supercoiled pentry/d-topo plasmid DNA.
Anahtar Kelimeler
Copper (II) complexes | DFT calculations | DNA binding | DNA cleavage | Schiff base complexes
Makale Türü Özgün Makale
Makale Alt Türü SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale
Dergi Adı Journal of the Mexican Chemical Society
Dergi ISSN 2594-0317
Dergi Tarandığı Indeksler SCI-Expanded
Dergi Grubu Q4
Makale Dili İngilizce
Basım Tarihi 04-2018
Cilt No 62
Sayı 3
Sayfalar 51 / 66
Doi Numarası 10.29356/jmcs.v62i3.424
Makale Linki https://www.jmcs.org.mx/index.php/jmcs/article/view/424