Effect of Positive Surgical Margins on Biochemical Failure, Biochemical Recurrence-free Survival, and Overall Survival After Radical Prostatectomy: Median Long-term Results
Yazarlar (7)
Hacettepe Üniversitesi, Türkiye
Dr. Sami Ulus Education & Research Hospital, Türkiye
Ankara Training & Research Hospital, Türkiye
Doç. Dr. Mümtaz DADALI
Kırşehir Ahi Evran Üniversitesi, Türkiye
Ankara Training & Research Hospital, Türkiye
Ankara Training & Research Hospital, Türkiye
Ondokuz Mayıs Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | KAOHSIUNG JOURNAL OF MEDICAL SCIENCES (Q3) | ||
| Dergi ISSN | 1607-551X Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 10-2014 |
| Cilt / Sayı / Sayfa | 30 / 10 / 510–514 | DOI | 10.1016/j.kjms.2014.04.001 |
| Makale Linki | http://dx.doi.org/10.1016/j.kjms.2014.04.001 | ||
| Özet |
| The aim of this study was to investigate the median long-term effects of positive surgical margin (PSM) and other prognostic factors on biochemical recurrence-free survival, overall survival, and biochemical failure in patients who underwent radical prostatectomy. Our study included 121 patients with pT2-3N0 disease treated between March 2006 and August 2012. The patients were divided into two groups: those with PSM and those with negative surgical margin (NSM). We analyzed the age, clinical and pathological stages, preoperative and postoperative Gleason scores, duration of the follow-up, adjuvant chemo-/radiotherapy, biochemical failure, biochemical recurrence-free survival, and overall survival in these patients. PSM was found in 25 (20%) patients, whereas 96 patients had NSM. The median follow-up time was 46.6 months (range 12-72 months) for the PSM group and 48.3 months (range 7-149 months) for the NSM group. The biochemical failure rate was 24% in the PSM group and 8.3% in the NSM group (p = 0.029). The biochemical recurrence-free survival was found as 76% in the PSM group and 91.7% in the NSM group. The difference between the groups was not statistically significant (p = 0.06). The overall survival was 100% in both groups. The surgical margins of the radical prostatectomy material is an important pathological indicator for biochemical failure at mid long-term follow-up. We did not find any effect of PSM on overall survival or biochemical recurrence-free survival. Copyright (C) 2014, Kaohsiung Medical University. Published by Elsevier Taiwan LLC. All rights reserved. |
| Anahtar Kelimeler |
| Biochemical failure | Prostatectomy | Prostatic neoplasm | Survival |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 1 |