| Yazarlar |
Unal Uluca
|
|
Aydin Ece
|
|
Velat Sen
|
|
Duran Karabel
|
|
Servet Yel
|
Prof. Dr. Ali GÜNEŞ
Kırşehir Ahi Evran Üniversitesi |
|
Ilhan Tan
|
|
Muhammed Sabas
|
| Özet |
| Background: Familial Mediterranean fever (FMF) is an autoinflammatory disease characterized by recurrent attacks of serositis, fever, and rash. Clinical and subclinical inflammatory processes may contribute to atherosclerosis in FMF patients, with mean platelet volume (MPV) as a potential indicator for atherosclerosis risk and neutrophil-tolymphocyte ratio (NLR) as a marker for subclinical inflammation in these patients. In this study, we investigated whether MPV can be used as an indicator for atherosclerosis risk and if NLR is a marker for subclinical inflammation in FMF patients. Material/Methods: The study consisted of 75 FMF patients in attack, 157 attack-free patients, and 77 healthy controls. White blood cell count neutrophil-to-lymphocyte ratio, platelet count, MPV, PDW C-reactive protein levels, and erythrocyte sedimentation rate were recorded. Results: There were no significant differences between attack, attack-free, and control groups in terms of mean MPV and PDW value. NLR value was higher in the attack group. NLR value was similar in attack-free and control groups. Conclusions: We found that MPV and PDW values are similar in FMF patients and healthy controls. NLR was higher in FMF patients in the attack period. Therefore, our results suggest that MPV and PDW values do not predict atherosclerosis risk in pediatric FMF patients, and NLR may be an indicator for attack period but not attack-free period. |
| Anahtar Kelimeler |
| Atherosclerosis | Familial Mediterranean Fever | Inflammation | Mean Platelet Volume |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | MEDICAL SCIENCE MONITOR |
| Dergi ISSN | 1643-3750 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 09-2014 |
| Cilt No | 20 |
| Sayı | 1 |
| Sayfalar | 1578 / 1582 |
| Doi Numarası | 10.12659/MSM.892139 |
| Atıf Sayıları | |
| WoS | 29 |
| SCOPUS | 26 |
| Google Scholar | 41 |
