Angiotensin converting enzyme and angiotensin II type 1 receptor gene polymorphisms in children with subacute sclerosing panencephalitis
Yazarlar (6)
Nebahat Tasdemir
Dicle Üniversitesi, Türkiye
Dicle Üniversitesi, Türkiye
Aydin Ece
Dicle Üniversitesi, Türkiye
Dicle Üniversitesi, Türkiye
Selahattin Tekes
Dicle Üniversitesi, Türkiye
Dicle Üniversitesi, Türkiye
Suber Dikici
Diyarbakir Devlet Hastanesi, Türkiye
Diyarbakir Devlet Hastanesi, Türkiye
Prof. Dr. Ali GÜNEŞ Dicle Üniversitesi, Türkiye
Hasan Balik
Dicle Üniversitesi, Türkiye
Dicle Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | American Journal of Medical Genetics Part B Neuropsychiatric Genetics | ||
| Dergi ISSN | 1552-4841 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SSCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 07-2006 |
| Kabul Tarihi | 12-04-2026 | Yayınlanma Tarihi | 01-06-2006 |
| Cilt / Sayı / Sayfa | 141 / 5 / 445–448 | DOI | 10.1002/ajmg.b.30343 |
| Makale Linki | https://onlinelibrary.wiley.com/doi/10.1002/ajmg.b.30343 | ||
| Özet |
| Subacute sclerosing panencephalitis (SSPE) is a progressive, debilitating, and fatal brain disorder caused by mutant measles virus infection. Although both viral and host factors seem to be involved in SSPE, the exact pathogenesis remains to be determined. Autoimmune demyelination is characteristic of SSPE. The blood angiotensin‐converting enzyme (ACE) activity and angiotensin II (Ang II) levels are associated with the ACE gene polymorphism. Proinflammatory effects of Ang II may contribute to the development of SSPE. The aim of this study was to investigate whether the ACE and Ang II type 1 receptor (AT1R) (A1166C) gene polymorphisms were associated with SSPE. The polymorphisms were investigated by polymerase chain reaction (PCR) in 43 patients with SSPE and 100 healthy controls. The genotype distribution of the SSPE children and healthy controls were as follows: DD 58.1% versus 34.0, ID … |
| Anahtar Kelimeler |
| ACE | AT1R | Gene polymorphism | Pathogenesis | SSPE |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 10 |
| Scopus | 2 |
| Web of Science | 7 |