The effects of pomegranate and carvacrol on methotrexate induced bone marrow toxicity in rat
Yazarlar (9)
Prof. Dr. Velat Şen Dicle Üniversitesi, Türkiye
Mehtap Bozkurt
Dicle Üniversitesi, Türkiye
Dicle Üniversitesi, Türkiye
Prof. Dr. Sevda Söker Dicle Üniversitesi, Türkiye
Aydın Ece
Dicle Üniversitesi, Türkiye
Dicle Üniversitesi, Türkiye
Prof. Dr. Ali GÜNEŞ Dicle Üniversitesi, Türkiye
Ünal Uluca
Dicle Üniversitesi, Türkiye
Dicle Üniversitesi, Türkiye
Prof. Dr. Murat Söker Dicle Üniversitesi, Türkiye
Dr. Öğr. Üyesi Servet Yel Yüzüncü Yıl Üniversitesi, Türkiye
Prof. Dr. İbrahim Kaplan Dicle Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Clinical and Investigative Medicine | ||
| Dergi ISSN | 0147-958X Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SSCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 04-2014 |
| Cilt / Sayı / Sayfa | 37 / 2 / – | DOI | 10.25011/CIM.V37I2.21091 |
| Makale Linki | https://utppublishing.com/doi/10.25011/cim.v37i2.21091 | ||
| UAK Araştırma Alanları |
Çocuk Sağlığı ve Hastalıkları (Çocuk Sağlığı ve Hastalıkları)
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| Özet |
| Purpose The aim of this study was to evaluate the effects of pomegranate (PMG) extract and carvacrol (CARV) on methotrexate (MTX)-induced oxidative stress and bone marrow toxicity. Methods Wistar albino rats (32 rats) were divided into four groups (n=8): Group 1 was control; Group 2 was given a single intraperitoneal injection of methotrexate (20 mg/kg); Group 3 was treated with carvacrol (73 mg/kg i.p.) one day before MTX (20 mg/kg i.p.) injection; and, Group 4 received a single dose of MTX (20 mg/kg i.p) while PMG was administered orally for seven days at 225 mg/kg. After animals were euthanized, blood samples were taken to evaluate hematological parameters and oxidative stress. In addition, the femur was cropped and bone marrow was extracted for examination. Results White blood cell count, hemoglobin, hematocrit and platelet count were found to be decreased in the MTX group, but these … |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 6 |
| Scopus | 11 |
| Google Scholar | 14 |