Role of Ankaferd on bacterial translocation and inflammatory response in an experimental rat model of intestinal obstruction
Yazarlar (9)
Velat Şen Dicle University, Faculty Of Medicine, Türkiye
Ünal Uluca Dicle University, Faculty Of Medicine, Türkiye
Aydın Ece Dicle University, Faculty Of Medicine, Türkiye
Prof. Dr. Ali GÜNEŞ Dicle University, Faculty Of Medicine, Türkiye
Hikmet Zeytun Dicle University, Faculty Of Medicine, Türkiye
Serkan Arslan Dicle University, Faculty Of Medicine, Türkiye
İbrahim Kaplan Dicle University, Faculty Of Medicine, Türkiye
G. Türkçü Dicle University, Faculty Of Medicine, Türkiye
Recep Tekin Dicle University, Faculty Of Medicine, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | International Journal of Clinical and Experimental Medicine (Q4) | ||
| Dergi ISSN | 1940-5901 Dergi Bilgileri (2015) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2015 |
| Cilt / Sayı / Sayfa | 7 / 9 / 2677–2686 | DOI | – |
| UAK Araştırma Alanları |
Çocuk Sağlığı ve Hastalıkları (Çocuk Sağlığı ve Hastalıkları)
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| Özet |
| Intestinal obstruction (IO) is an important risk factor for the development of bacteria translocation (BT), a serious condition associated with sepsis and potential mortality. Ankaferd is an herbal extract that is reported to exert anti-hemorrhagic, anti-oxidant, anti-microbial, and anti-inflammatory, effects in the intestine. In this study, we employed an animal model of intestinal obstruction to evaluate the effects of Ankaferd in the prevention of bacterial translocation and the suppression of the inflammatory response. Thirty male Wistar Albino rats were allocated randomly to three groups: Group 1 (sham) underwent ileal manipulation alone; Group 2 (intestinal obstruction, IO) underwent complete ileal ligation; Group 3 (intestinal obstruction + Ankaferd blood stopper, ABS) underwent complete ileal ligation and intraperitoneal Ankaferd injection. All rats were euthanized after 24 hours. Blood samples were collected for the … |
| Anahtar Kelimeler |
| Ankaferd | Bacterial translocation | Cytokines | Intestinal obstruction | Oxidative stress |
