| Yazarlar |
Unal Uluca
|
|
Velat Sen
|
|
Aydin Ece
|
|
Ilhan Tan
|
|
Duran Karabel
|
|
Fesih Aktar
|
|
Musemma Karabel
|
|
Hasan Balik
|
Ali GÜNEŞ
Kırşehir Ahi Evran Üniversitesi |
| Özet |
| Background: Chronic hepatitis B virus (HBV) infection is common worldwide. Follow-up of patients by the use of non-invasive techniques may be valuable in clinical practice. The aim of this study was to investigate serum galectin-3 (GAL-3) levels for monitoring disease status in children with chronic HBV infection. Material/Methods: Thirty-two patients with chronic hepatitis B (CHB), 30 inactive HBV carrier patients, and 30 matched healthy controls were enrolled in the study. We performed basic laboratory tests: serum glucose, albumin, alanine aminotransferase (ALT), aspartate aminotransferase, gamma-glutamyl transferase (GGT), total bilirubin, prothrombin time, and activated partial thromboplastin time. In addition, serum GAL-3 levels were measured by ELISA technique. Results: Significantly higher serum GAL-3 levels (16.5 +/- 3.6, 1.1 +/- 0.3, 0.7 +/- 0.5 ng/ml, respectively, p<0.001) and ALT levels (80.2 +/- 30.6, 26.8 +/- 12.6, 28.1 +/- 4.4 IU/L, respectively, p<0.001) were found in the CHB group compared with the inactive carriers and the control groups. There were no significant differences in ALT levels and GAL-3 levels or between inactive HBV carriers and the control groups (p>0.05, for each). Significantly higher GGT levels were found in the CHB group (51.3 +/- 27.5 IU/L) compared with the inactive HBV carriers (35.7 +/- 10.1 IU/L) and the control group (31.3 +/- 9.5 IU/L) (p<0.001, and p=0.004, respectively). A significant correlation was found between GAL-3 and ALT levels in the CHB group (r=0.82, p<0.001). Conclusions: Our results suggest that serum GAL-3 level may be a beneficial indicator of chronicity in hepatitis B infection in children. |
| Anahtar Kelimeler |
| Child | Chronic | Galectin 3 | Hepatitis B |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | MEDICAL SCIENCE MONITOR |
| Dergi ISSN | 1643-3750 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 05-2015 |
| Cilt No | 21 |
| Sayı | 1 |
| Sayfalar | 1376 / 1380 |
| Doi Numarası | 10.12659/MSM.894035 |
| Atıf Sayıları | |
| SCOPUS | 24 |
| Google Scholar | 31 |
