| Yazarlar |
Unal Uluca
|
|
Fikri Demir
|
|
Aydin Ece
|
|
Velat Sen
|
Ali GÜNEŞ
Kırşehir Ahi Evran Üniversitesi |
|
Fesih Aktar
|
|
Ilhan Tan
|
|
Duran Karabel
|
|
Umitcan Yazgan
|
|
Muhammed Nurullah Sabaz
|
| Özet |
| Background: Familial Mediterranean fever (FMF) is an inflammatory disease, which is suggested to be associated with increased risk of atherosclerosis. Epicardial adipose tissue (EAT) thickness and the mean platelet volume (MPV) are parameters used in prediction of atherosclerotic risk in various conditions. These parameters were evaluated in children with FMF and compared with healthy controls. Methods: Forty-five patients with FMF and 54 age-and gender-matched healthy controls were assessed. Duration of symptoms, age at diagnosis, duration of delay in diagnosis, frequency and duration of FMF attacks, disease severity scores, response to colchicine therapy, MEditerraneanFeVer (MEFV) gene mutations, and MPV values were recorded. EAT thicknesses were measured by echocardiography. Results: Epicardial adipose tissue thicknesses of the children with FMF were found to be significantly greater than that of controls (5.1 +/- 1.4 vs. 4.5 +/- 0.9 mm, p = 0.036). FMF patients had significantly higher MPV values compared with the controls (7.8 +/- 1.1 vs. 7.3 +/- 1.4 fl, p = 0.044). Age at diagnosis, duration of delay in diagnosis, and MPV values were found to be correlated with EAT thickness in the patient group (r = 0.49, p = 0.001 for the former parameters and r = 0.32, p = 0.04 for MPV). Conclusion: Epicardial adipose tissue thickness and MPV values seem to be increased in children with FMF. These findings may indicate an increased risk of atherosclerosis in FMF patients. |
| Anahtar Kelimeler |
| Atherosclerosis | Epicardial adipose tissue thickness | Familial Mediterranean fever | Inflammation | Mean platelet volume |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | ITALIAN JOURNAL OF PEDIATRICS |
| Dergi ISSN | 1720-8424 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 02-2015 |
| Cilt No | 41 |
| Sayı | 1 |
| Sayfalar | 15 / 0 |
| Doi Numarası | 10.1186/s13052-015-0120-z |
| Atıf Sayıları | |
| WoS | 17 |
| SCOPUS | 16 |
| Google Scholar | 22 |
