| Yazarlar |
Fesih Aktar
|
|
Recep Tekin
|
|
Mehmet Selcuk Bektas
|
Ali GÜNEŞ
Kırşehir Ahi Evran Üniversitesi |
|
Muhammet Kosker
|
|
Sabahattin Ertugrul
|
|
Kamil Yilmaz
|
|
Kamuran Karaman
|
|
Hasan Balik
|
|
Ilyas Yolbas
|
| Özet |
| Background: As a multisystem infectious disease, there is an inflammation, which causes increase in acute phase reactants in brucellosis. The mean platelet volume (MPV), platelet distribution width (PDW), red cell distribution width (RDW), neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) have been identified as markers of inflammation. The present study aimed to evaluate diagnostic values of these biomarkers in brucella arthritis (BA). Methods: The study included 64 children with BA and 66 healthy control subjects. Demographic features, joint involvement, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and hematological variables were retrospectively recorded. In addition, results of synovial fluid and serum tube agglutination test for brucella together with treatment regimens were recorded. Results: The mean age of the patients (53.1 % male) was 92.3 +/- 41.2 months. The most commonly affected joint was ankle (53.1 %). Synovial fluid puncture-brucella agglutination test was positive in 22 (34.3 %) patients. Puncture culture was positive in 9 patients. Most of the patients (57.8 %) were treated with a combination of rifampicin plus sulfamethoxazole/trimethoprim and gentamicin. Significantly higher mean PDW, RDW, MPV, NLR and PLR values were found in children with BA compared to control subjects (p < 0.05). A positive correlation was found between MPV and NLR values (R-2 = 0.192, p < 0.001). Conclusion: Our findings indicated that NLR and PLR are indirect markers of inflammation that may be observed abnormally increased in children with brucella arthritis. Further longitudinal studies are needed to investigate this topic to establish the more clear associations. |
| Anahtar Kelimeler |
| Brucella arthritis | Child | Correlation | Diagnostic role | Inflammatory markers |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | ITALIAN JOURNAL OF PEDIATRICS |
| Dergi ISSN | 1720-8424 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2016 |
| Cilt No | 42 |
| Sayı | 1 |
| Doi Numarası | 10.1186/s13052-016-0211-5 |
| Makale Linki | http://www.ijponline.net/content/42/1/3 |
| Atıf Sayıları | |
| WoS | 35 |
| SCOPUS | 30 |
| Google Scholar | 67 |
