| Yazarlar |
Prof. Dr. Ali GÜNEŞ
Kırşehir Ahi Evran Üniversitesi |
Fesih Aktar
|
|
Ilhan Tan
|
|
Murat Soker
|
|
Unal Uluca
|
|
Hasan Balik
|
|
Nuriye Mete
|
| Özet |
| The aim of this study was to investigate urine early kidney injury molecules, including human kidney injury molecule-1 (KIM-1), liver-type fatty-acid binding protein (L-FABP), N-acetyl-b-D-glucosaminidase A (NAG), and neutrophil gelatinase-associated lipocalin (NGAL) in children with vitamin B12 (cobalamin) deficiency (CD). Twelve children with vitamin B12 deficiency and 20 healthy matched controls were included. Hematologic parameters, serum urea, creatinine (Cr), electrolytes, B12 and folate levels were recorded. Estimated glomerular filtration rate (eGFR) was calculated. Urine protein, electrolytes, and urinary early markers were measured. Patients with CD had significantly higher urine electrolyte/Cr ratios (p < 0.05). Significantly higher urinary KIM-1/Cr, L-FABP/Cr, NAG/Cr and NGAL/Cr were found in CD group (p < 0.05). Significant negative correlations were found between levels of serum B12 and urinary markers in the patients (p < 0.05). Increased urinary kidney injury molecules and electrolytes in children with B12 deficiency suggest a possible subclinical renal dysfunction, which cannot be determined by conventional kidney function tests. |
| Anahtar Kelimeler |
| vitamin B12 deficiency, kidney injury, KIM-1, L-FABP, NAG, NGAL |
| Makale Türü | Diğer (Teknik, not, yorum, vaka takdimi, editöre mektup, özet, kitap krıtiği, araştırma notu, bilirkişi raporu ve benzeri) |
| Makale Alt Türü | SCI, SSCI, AHCI, SCI-Exp dergilerinde yayımlanan teknik not, editöre mektup, tartışma, vaka takdimi ve özet türünden makale |
| Dergi Adı | Archivos Argentinos de Pediatria |
| Dergi ISSN | 0325-0075 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 10-2016 |
| Cilt No | 114 |
| Sayı | 5 |
| Doi Numarası | 10.5546/aap.2016.eng.453 |
| Makale Linki | http://www.sap.org.ar/docs/publicaciones/archivosarg/2016/v114n5a14e.pdf |
| Atıf Sayıları | |
| WoS | 3 |
| SCOPUS | 4 |
| Google Scholar | 6 |
