| Yazarlar |
Prof. Dr. Ali GÜNEŞ
Kırşehir Ahi Evran Üniversitesi |
Aydin Ece
|
|
Halise Akca
|
|
Fesih Aktar
|
|
Sehmus Mete
|
|
Serhat Samanci
|
|
Unal Uluca
|
|
Velat Sen
|
|
Ilhan Tan
|
|
Ibrahim Kaplan
|
| Özet |
| Objective: Hypoxia occurs following convulsions, and hypoxia is one of the most common causes of acute renal damage. The aim of this study was to investigate urinary levels of kidney injury molecules, including neutrophil gelatinase-associated lipocalin (NGAL), N-acetyl--D-glucosaminidase (NAG), and liver-type fatty acid-binding protein (L-FABP) in children with febrile seizures (FS) for the first time.Methods: The study included 28 children with FS and 34 age and gender matched healthy children. Serum biochemistry and blood gases were measured in the serum samples. Estimated glomerular filtration rate (eGFR) was calculated. NGAL, NAG, L-FABP, and creatinine (Cr) were measured in the urine samples. The ratios of kidney injury markers to urinary Cr were used for comparisons.Results: There were no significant differences in eGFR and serum chemistry values between the FS and the control group (p>0.05). Hypoxia was detected in 67.9% of the FS patients. The FS group had significantly higher urinary kidney injury molecules to Cr ratios compared to the controls, including NGAL/Cr (17.99.8; 6.7 +/- 4.0, respectively; p<0.001), NAG/Cr (0.55 +/- 0.29; 0.21 +/- 0.16, p<0.001), and L-FABP/Cr (4.85 +/- 2.93; 1.74 +/- 1.16, p<0.001).Conclusion: Increased urinary NGAL/Cr, NAG/Cr, and L-FABP/Cr values, in patients with FS compared to healthy controls, suggest a possible subclinical renal damage in these patients. |
| Anahtar Kelimeler |
| Febrile convulsion, kidney injury, urinary markers, NGAL, NAG, L-FABP |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Renal Failure |
| Dergi ISSN | 0886-022X |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 08-2016 |
| Sayfalar | 1 / 6 |
| Doi Numarası | 10.1080/0886022X.2016.1215198 |
| Makale Linki | https://www.tandfonline.com/doi/full/10.1080/0886022X.2016.1215198 |
| Atıf Sayıları | |
| WoS | 3 |
| SCOPUS | 3 |
| Google Scholar | 4 |
