| Yazarlar |
Prof. Dr. Ali GÜNEŞ
Kırşehir Ahi Evran Üniversitesi |
Aydin Ece
|
|
Fesih Aktar
|
|
Ilhan Tan
|
|
Murat Soker
|
|
Duran Karabel
|
|
Hasan Balik
|
|
Unal Uluca
|
|
Velat Sen
|
|
Ilyas Yolbas
|
| Özet |
| Background: The aim of this study was to investigate the urine levels of human kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), N-acetyl-beta-D-glucosaminidase (NAG), and liver-type fatty acid-binding protein (L-FABP) in children with iron-deficiency anemia (IDA). Material/Methods: Thirty-five children with IDA and 32 matched healthy controls were recruited. We assessed complete blood count, serum iron, iron-binding capacity, ferritin, serum levels of urea, creatinine (Cr), sodium (Na), potassium (K), calcium (Ca), and glucose levels. Estimated glomerular filtration rate (eGFR) was calculated. Urinary NAG, NGAL, KIM-1, and L-FABP were measured and divided by urine creatinine for comparisons. Results: There were no significant differences in serum urea, Cr, or eGFR between the IDA group and the control group (p>0.05, for all). IDA patients had significantly higher urine NGAL/Cr, L-FABP/Cr, KIM-1/Cr, and NAG/Cr compared with the control group (p<0.05). There were significant negative correlations between hemoglobin, hematocrit, red blood cell count, and urine NGAL/Cr, NAG/Cr, L-FABP/Cr, KIM-1/Cr levels (p<0.05). Conclusions: Higher urinary kidney injury molecule levels in IDA patients suggest a possible subclinical renal injury in pediatric IDA patients whose renal functions and serum electrolytes were normal. |
| Anahtar Kelimeler |
| Anemia | Early diagnosis | Iron-deficiency | Kidney diseases |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | MEDICAL SCIENCE MONITOR |
| Dergi ISSN | 1643-3750 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 12-2015 |
| Cilt No | 21 |
| Sayı | 1 |
| Sayfalar | 4023 / 4029 |
| Doi Numarası | 10.12659/MSM.896794 |
| Makale Linki | http://www.medscimonit.com/abstract/index/idArt/896794 |
| Atıf Sayıları | |
| WoS | 6 |
| SCOPUS | 6 |
| Google Scholar | 10 |
