| Yazarlar |
Bülent Behlül Altunkeser
Selçuk Üniversitesi, Türkiye |
|
Abdullah Tunçez
Selçuk Üniversitesi, Türkiye |
|
Bahadır Öztürk
Selçuk Üniversitesi, Türkiye |
|
Hüseyin Tezcan
Selçuk Üniversitesi, Türkiye |
Dr. Öğr. Üyesi Muhammet Salih ATEŞ
Selçuk Üniversitesi, Türkiye |
|
Canan Yılmaz
Türkiye |
|
Muhammed Ulvi Yalçın
Selçuk Üniversitesi, Türkiye |
|
Nazif Aygül
Selçuk Üniversitesi, Türkiye |
|
Kenan Demir
Selçuk Üniversitesi, Türkiye |
| Özet |
| Aim Current guidelines recommend administration of high-dose statins in acute coronary syndrome (ACS). It has been reported that statins upregulate proprotein convertase subtilisin kexin 9 (PCSK9) mRNA expression and increase circulating PCSK9 levels. We aimed to compare the effects of high-dose atorvastatin and rosuvastatin on serum oxidized low-density lipoprotein (oxidized-LDL) and PCSK9 levels in statin-naive patients with ACS. Patients and methods One hundred and six patients with ACS were enrolled in this study. The patients were assigned randomly to receive atorvastatin (80 mg/day) or rosuvastatin (40 mg/day) by using a ratio of 1 : 1 in randomization. The levels of total cholesterol (TC), triglyceride, high-density lipoprotein cholesterol, LDL-cholesterol, oxidized-LDL, and PCSK9 were compared between groups after a 4-week treatment. Results Our study population included 53 patients in the atorvastatin group (age: 58.13 +/- 11.30 years, 11.32% female) and 53 patients in the rosuvastatin group (age: 59.08 +/- 12.44 years, 15.09% female). In both groups, lipid parameters, oxidized-LDL, and PCSK9 values changed significantly according to the baseline following treatment. High-dose atorvastatin and rosuvastatin induced similar decreases in LDL-cholesterol, oxidized-LDL, and triglyceride levels and similarly increased in high-density lipoprotein cholesterol and PCSK9 levels (P>0.05). Conclusion We showed that atorvastatin and rosuvastatin treatment regimens have comparable effects on lipid parameters and PCSK9 levels in ACS patients. |
| Anahtar Kelimeler |
| acute coronary sydrome, oxidized low-density lipoprotein, proprotein convertase subtilisin kexin 9 |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Coronary Artery Disease |
| Dergi ISSN | 0954-6928 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2019 |
| Cilt No | 30 |
| Sayı | 4 |
| Sayfalar | 285 / 290 |
| Doi Numarası | 10.1097/MCA.0000000000000715 |
| Makale Linki | https://journals.lww.com/00019501-201906000-00007 |
| Atıf Sayıları | |
| WoS | 6 |
| Google Scholar | 11 |
