| Yazarlar (7) |
Hakan Parlakpınar
İnönü Üniversitesi, Türkiye |
|
Mehmet Kaya Özer
Adıyaman Üniversitesi, Türkiye |
|
Muharrem Uçar
İnönü Üniversitesi, Türkiye |
Prof. Dr. Muhammet GAFFAROĞLU
Ahi Evran Üniversitesi, Türkiye |
|
Nigar Vardı
İnönü Üniversitesi, Türkiye |
|
Mustafa Koç
|
|
Hacı Ahmet Acet
İnönü Üniversitesi, Türkiye |
| Özet |
| Amikacin (AK) has nephrotoxic side effects. AK‐induced nephrotoxicity may be the consequence of oxidative stress and so anti‐oxidant agents could be useful in reducing AK toxicity. Caffeic acid phenethyl ester (CAPE) was recently shown to have free radical scavenging ability and it reduces lipid peroxidation. For this purpose, the rats were distributed into three groups: (I) injected with vehicle (control); (II) injected (i.p.) with 1.2 g kg−1 AK at a single dose; (III) injected (i.p.) with AK plus 10 µmol kg−1 CAPE. Renal morphology was investigated by light microscopy. Tissue samples and trunk blood were also obtained to determine renal malondialdehyde (MDA), blood urea nitrogen (BUN) and creatinine (Cr) levels. MDA production was found to be higher in rats given AK than among control rats. CAPE administration before AK injection caused a significant decrease in MDA production. Morphological tubule … |
| Anahtar Kelimeler |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | CELL BIOCHEMISTRY AND FUNCTION |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2006 |
| Cilt No | 24 |
| Sayı | 4 |
| Sayfalar | 363 / 367 |
| Doi Numarası | 10.1027/cbf.1264 |
| Atıf Sayıları | |
| Google Scholar | 34 |
