The effects of chronic exposure to ethanol and cigarette smoke on the formation of peroxynitrite level of nitric oxide xanthine oxidase and myeloperoxidase activities in rat kidney
Yazarlar (9)
Yılmaz Çiğremiş İnönü Üniversitesi, Türkiye
Yusuf Türköz İnönü Üniversitesi, Türkiye
Mehmet Tuzcu Fırat Üniversitesi, Türkiye
Hasan Özen Kafkas Üniversitesi, Türkiye
Asım Kart Mehmet Akif Ersoy Üniversitesi, Türkiye
Prof. Dr. Muhammet GAFFAROĞLU Kırşehir Ahi Evran Üniversitesi, Türkiye
Kenan Erdoğan Aksaray Üniversitesi, Türkiye
Müslüm Akgöz
Fikret Özuğurlu
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | MOLECULAR AND CELLULAR BIOCHEMISTRY | ||
| Dergi ISSN | 0300-8177 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 10-2006 |
| Kabul Tarihi | 12-04-2026 | Yayınlanma Tarihi | – |
| Cilt / Sayı / Sayfa | 291 / 1 / 127–138 | DOI | 10.1007/s11010-006-9205-8 |
| Makale Linki | http://link.springer.com/10.1007/s11010-006-9205-8 | ||
| Özet |
| The aim of this study was to investigate the effects of chronic ethanol intake and cigarette smoke exposure on rat kidney. The animals were divided into four experimental groups: (1) the control group (C), (2) the ethanol group (E), (3) the cigarette smoke group (CS), and (4) the cigarette smoke plus ethanol group (CS+E). Rats in E, CS and CS+E groups were treated with ethanol and/or cigarette smoke for 6 months. The animals were killed and the kidneys were removed to determine the activity of xanthine oxidase (XO), myeloperoxidase (MPO) and the levels of nitric oxide (NO). Histopathological and immunohistochemical analysis were performed in kidney tissues. The activity of XO/g protein were 2.8 ± 0.3, 5.2 ± 0.3, 3.2 ± 0.1, and 7.4 ± 0.7 U for C, E, CS and CS+E groups, respectively. In groups E, and CS+E, the XO values were significantly higher than in group C (P < 0.05). The increase in XO activity of CS was … |
| Anahtar Kelimeler |
| cigarette smoke | ethanol | MPO | nitric oxide | nitrotyrosine | kidney | XO |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 25 |
| Web of Science | 15 |