Ydj1 but not Sis1 stabilizes Hsp70 protein under prolonged stress in vitro
     
Yazarlar (2)
Dr. Öğr. Üyesi Lütfi TUTAR Kahramanmaraş Sütçü İmam Üniversitesi, Türkiye
Yusuf Tutar Cumhuriyet Üniversitesi, Türkiye
Makale Türü Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
Dergi Adı Biopolymers
Dergi ISSN 0006-3525 Wos Dergi Scopus Dergi
Dergi Tarandığı Indeksler SCI-Expanded
Makale Dili İngilizce Basım Tarihi 03-2008
Cilt / Sayı / Sayfa 89 / 3 / 171–174 DOI 10.1002/bip.20881
Makale Linki http://doi.wiley.com/10.1002/bip.20881
Özet
Yeast cytosol has two important co-chaperons; Ydj1 and Sis1. Genetic experiments showed that Ydj1 is not I essential for viability; however, cells lacking it grow very poorly at 30 degrees C or unable to grow at extreme temperatures. On the other hand, Sis1 is an essential protein and apparently plays a functional role at assembly or disassembly of protein complexes. Stability experiments revealed that only Ydj1-protected Hsp70 proteins can hydrolyze ATP under prolonged stress. (c) 2007 Wiley Periodicals, Inc.
Anahtar Kelimeler
stability, Hsp70, Ydj1, Sis1