Regulation of Heat Shock Proteins by miRNAs in Human Breast Cancer
Yazarlar (3)
Dr. Öğr. Üyesi Lütfi TUTAR
Kahramanmaraş Sütçü İmam Üniversitesi, Türkiye
Yusuf Tutar
Cumhuriyet Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (Uluslararası alan indekslerindeki dergilerde yayınlanan tam makale) | ||
| Dergi Adı | Microrna Shriqah United Arab Emirates | ||
| Dergi ISSN | 2211-5374 Scopus Dergi | ||
| Dergi Tarandığı Indeksler | MEDLINE, EMBASE, Chemical Abstracts, J-Gate, CNKI Scholar, Suweco CZ and EBSCO | ||
| Makale Dili | İngilizce | Basım Tarihi | 08-2014 |
| Cilt / Sayı / Sayfa | 3 / 2 / 118–135 | DOI | 10.2174/2211536604666141216214140 |
| Makale Linki | http://www.eurekaselect.com/openurl/content.php?genre=article&issn=2211-5366&volume=3&issue=2&spage=118 | ||
| Özet |
| Metabolic rates of cancer cells are faster compared to normal cells. This faster rate yields aberrant protein folding and causes loss of protein function. Therefore, cancer cells need more Heat Shock Proteins (HSPs) for proper substrate- protein folding on oncogenic pathways. Pseudogenes regulate tumor suppressors and oncogenes, and pseudogenes are deregulated in cancer progression. Further, alterations in miRNA expression have been identified in different cancer types. MiRNAs also have both oncogenic and tumour-suppressive roles in breast cancer post-transcriptional gene regulation. Breast cancer is a genetic disease and we performed miRNA analysis in human breast cancer cell lines to identify miRNAs in association with HSPs and pseudogenes by employing CellMiner; a web-based suite. CellMiner integrates several databases and help analysing microarray metadata. The experimental data … |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| SCOPUS | 25 |
| Google Scholar | 33 |