Therapeutic Targeting of microRNAs in Cancer Future Perspectives
Yazarlar (4)
Dr. Öğr. Üyesi Lütfi TUTAR
Kahramanmaraş Sütçü İmam Üniversitesi, Türkiye
Esen Tutar
Kahramanmaras Sütçü Imam Üniversitesi, Türkiye
Aykut Özgür
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Yusuf Tutar
Cumhuriyet Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Drug Development Research | ||
| Dergi ISSN | 0272-4391 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 11-2015 |
| Cilt / Sayı / Sayfa | 76 / 7 / 382–388 | DOI | 10.1002/ddr.21273 |
| Makale Linki | http://doi.wiley.com/10.1002/ddr.21273 | ||
| Özet |
| The discovery of microRNAs (miRNAs) and their link with cancer has opened a new era in cancer therapeutics. Approximately, 18-24 nucleotides long, miRNAs can up-regulate or down-regulate gene expression in many cancer types and are respectively categorized as oncogenes (oncomirs) or tumor suppressors. Expression profiles of miRNAs with biomarker potential can be used for the classification, diagnosis, therapeutic treatment, and prognosis of different cancer types. miRNA mimics and miRNA antagonists are the two main approaches to miRNA-based cancer therapies that respectively inhibit oncomirs or restore the expression of tumor suppressive miRNAs. This review serves to provide some general insight into miRNA biogenesis, cancer related miRNAs, and miRNA therapeutics. Drug Dev Res 76 : 382-388, 2015. (c) 2015 Wiley Periodicals, Inc. |
| Anahtar Kelimeler |
| microRNA, cancer, oncomir, tumor suppressor, therapeutics |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 60 |
| SCOPUS | 62 |
| Google Scholar | 84 |