Pyrazolyl‐Benzoxazinone Derivatives as Dual Hsp Inhibitors in Human Breast Cancer
Yazarlar (7)
İrfan Koca Yozgat Bozok University, Türkiye
Volkan Kamaci
Yozgat Bozok University, Türkiye
Yozgat Bozok University, Türkiye
Doç. Dr. Ceylan Özsoy Cumhuriyet Üniversitesi, Türkiye
Prof. Dr. Yusuf Sert Yozgat Bozok University, Türkiye
Prof. Dr. İbrahim Kani Eskisehir Technical University, Türkiye
Dr. Öğr. Üyesi Lütfi TUTAR Kırşehir Ahi Evran Üniversitesi, Türkiye
Prof. Dr. Yusuf Tutar University Of Health Sciences, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Chemistryselect (Q3) | ||
| Dergi ISSN | 2365-6549 Dergi Bilgileri (2022) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 05-2022 |
| Cilt / Sayı / Sayfa | 7 / 19 / – | DOI | 10.1002/slct.202200359 |
| Makale Linki | http://dx.doi.org/10.1002/slct.202200359 | ||
| UAK Araştırma Alanları |
Moleküler Biyoloji ve Genetik
|
||
| Özet |
| Heat Shock Proteins (Hsps) play major role on the onset of several cancers. Metabolic rates of cancer cells are higher compared to that of untransformed cells. This accelerated rate force functional substrate proteins to fold faster than normal folding rate. Although, the process leads cell cycle halting and eventually induces apoptosis, Hsps help cell survival and inhibit apoptosis and fold substrate proteins especially signaling proteins. When cancer cells accelerate the metabolism for invasion and metastasis, substrate proteins must fold to their native state rapidly. Since, functional forms of the proteins must be folded properly, cancer cells overexpress Hsps to fold substrate proteins and avoid apoptosis. Hsp90 and Hsp70 play key role in these processes. Inhibition of either Hsp90 or Hsp70 display complementary function. Therefore, dual inhibition of Hsp70 and Hsp90 potentially provides anticancer affect. In silico … |
| Anahtar Kelimeler |
| Benzoxazine | Breast Cancer | HSP | Molecular Docking | Pyrazole |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 5 |
| Scopus | 7 |
| Google Scholar | 6 |