| Yazarlar |
Doç. Dr. Burç Esra ŞAHİN
Kırşehir Ahi Evran Üniversitesi, Türkiye |
Asuman Çelikbilek
Kırşehir Ahi Evran Üniversitesi, Türkiye |
|
Yusuf Koçak
Tokat Gaziosmanpaşa Üniversitesi, Türkiye |
Doç. Dr. Bilal İLANBEY
Kırşehir Ahi Evran Üniversitesi, Türkiye |
Dr. Öğr. Üyesi Gamze TURNA SALTOĞLU
Kırşehir Ahi Evran Üniversitesi, Türkiye |
|
Naime Meriç Konar
Kırşehir Ahi Evran Üniversitesi, Türkiye |
Dr. Öğr. Üyesi Lokman HİZMALİ
Kırşehir Ahi Evran Üniversitesi, Türkiye |
| Özet |
| A wide spectrum of neurological symptoms (NS) has been described in patients with COVID-19. We examined the plasma levels of neuron-specific enolase (NSE) and neurofilament light chain (NFL) together, as neuronal damage markers, and their relationships with clinical severity in patients with NS at acute COVID-19. A total of 20 healthy controls and 59 patients with confirmed COVID-19 were enrolled in this pilot prospective study. Serum NSE and NFL levels were measured by using the enzyme-linked immunoassay method from serum samples. Serum NSE levels were found to be significantly higher in the severe group than in the nonsevere group (p = 0.034). However, serum NFL levels were similar between the control and disease groups (p > 0.05). For the mild group, serum NFL levels were significantly higher in patients with the sampling time >= 5 days than in those with the sampling time <5 days (p = 0.019). However, no significant results for NSE and NFL were obtained in patients with either single or multiple NS across the groups (p > 0.05). Increased serum NSE levels were associated with disease severity regardless of accompanied NS in patients with acute COVID-19 infection. However, serum NFL levels may have a role at the subacute phase of COVID-19. |
| Anahtar Kelimeler |
| COVID-19 | neurofilament light chain | neurological symptoms | neuron-specific enolase | neuronal damage |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | JOURNAL OF MEDICAL VIROLOGY |
| Dergi ISSN | 0146-6615 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2023 |
| Cilt No | 95 |
| Sayı | 1 |
| Doi Numarası | 10.1002/jmv.28240 |
| Makale Linki | https://onlinelibrary.wiley.com/doi/epdf/10.1002/jmv.28240 |
| Atıf Sayıları | |
| WoS | 7 |
