Neurological symptoms and neuronal damage markers in acute COVID-19: Is there a correlation? A pilot study
Yazarlar (7)
Doç. Dr. Burç Esra ŞAHİN
Kırşehir Ahi Evran Üniversitesi, Türkiye
Kırşehir Ahi Evran Üniversitesi, Türkiye
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Doç. Dr. Bilal İLANBEY
Kırşehir Ahi Evran Üniversitesi, Türkiye
Dr. Öğr. Üyesi Gamze TURNA SALTOĞLU
Kırşehir Ahi Evran Üniversitesi, Türkiye
Kırşehir Ahi Evran Üniversitesi, Türkiye
Dr. Öğr. Üyesi Lokman HİZMALİ
Kırşehir Ahi Evran Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
|
||
| Dergi Adı | JOURNAL OF MEDICAL VIROLOGY (Q1) | ||
| Dergi ISSN | 0146-6615 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2023 |
| Cilt / Sayı / Sayfa | 95 / 1 / – | DOI | 10.1002/jmv.28240 |
| Makale Linki | https://onlinelibrary.wiley.com/doi/epdf/10.1002/jmv.28240 | ||
| Özet |
| A wide spectrum of neurological symptoms (NS) has been described in patients with COVID-19. We examined the plasma levels of neuron-specific enolase (NSE) and neurofilament light chain (NFL) together, as neuronal damage markers, and their relationships with clinical severity in patients with NS at acute COVID-19. A total of 20 healthy controls and 59 patients with confirmed COVID-19 were enrolled in this pilot prospective study. Serum NSE and NFL levels were measured by using the enzyme-linked immunoassay method from serum samples. Serum NSE levels were found to be significantly higher in the severe group than in the nonsevere group (p = 0.034). However, serum NFL levels were similar between the control and disease groups (p > 0.05). For the mild group, serum NFL levels were significantly higher in patients with the sampling time >= 5 days than in those with the sampling time <5 days (p = 0.019). However, no significant results for NSE and NFL were obtained in patients with either single or multiple NS across the groups (p > 0.05). Increased serum NSE levels were associated with disease severity regardless of accompanied NS in patients with acute COVID-19 infection. However, serum NFL levels may have a role at the subacute phase of COVID-19. |
| Anahtar Kelimeler |
| COVID-19 | neurofilament light chain | neurological symptoms | neuron-specific enolase | neuronal damage |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 9 |