Associations of the neutrophil/lymphocyte ratio, monocyte/ lymphocyte ratio, and platelet/lymphocyte ratio with COVID-19 disease severity in patients with neurological symptoms: A cross-sectional monocentric study
 
Yazarlar (5)
Doç. Dr. Burç Esra ŞAHİN Kırşehir Ahi Evran Üniversitesi, Türkiye
Asuman Çelikbilek Kırşehir Ahi Evran Üniversitesi, Türkiye
Yusuf Koçak Kirsehir Ahi Evran University, Türkiye
Dr. Öğr. Üyesi Aydan KÖYSÜREN Kırşehir Ahi Evran Üniversitesi, Türkiye
Dr. Öğr. Üyesi Lokman HİZMALİ Kırşehir Ahi Evran Üniversitesi, Türkiye
Makale Türü Açık Erişim Özgün Makale (ESCI dergilerinde yayınlanan tam makale)
Dergi Adı JOURNAL OF NEUROSCIENCES IN RURAL PRACTICE
Dergi ISSN 0976-3147 Wos Dergi Scopus Dergi
Dergi Tarandığı Indeksler SCI-Expanded
Makale Dili İngilizce Basım Tarihi 04-2023
Kabul Tarihi – Yayınlanma Tarihi 22-10-2022
Cilt / Sayı / Sayfa 14 / 2 / 224–229 DOI 10.25259/JNRP_6_2022
Makale Linki http://dx.doi.org/10.25259/jnrp_6_2022
Özet

Objectives:
Data are limited regarding the relationship of neutrophil/lymphocyte ratio (NLR), monocyte/lymphocyte ratio (MLR), and platelet/ lymphocyte ratio (PLR) with neurological symptoms (NS) in COVID-19 patients. This study is the first to assess the utility of the NLR, MLR, and PLR for predicting COVID-19 severity in infected patients with NS.


Materials and Methods:
Consecutive 192 PCR-positive COVID-19 patients with NS were included in this cross-sectional and prospective study. The patients were classified into the non-severe and severe groups. We analyzed routinely complete blood count in these groups in terms of COVID-19 disease severity.


Results:
Advanced age, a higher body mass index, and comorbidities were significantly more common in the severe group (P < 0.001). Among the NS, anosmia (P = 0.001) and memory loss (P = 0.041) were significantly more common in the non-severe group. In the severe group, the lymphocytes and monocyte counts and the hemoglobin level were significantly lower, while the neutrophil count, NLR, and PLR were significantly higher (all P < 0.001). In the multivariate model, advanced age and a higher neutrophil count were independently associated with severe disease (both P < 0.001) but the NLR and PLR were not (both P > 0.05).


Conclusion:
We found positive associations of COVID-19 severity with the NLR and PLR in infected patients with NS. Further research is required to shed more light on the role of neurological involvement in disease prognosis and outcomes.
Anahtar Kelimeler
COVID-19 | Monocyte to lymphocyte ratio | Neurological symptoms | Neutrophil to lymphocyte ratio | Platelet to lymphocyte ratio
BM Sürdürülebilir Kalkınma Amaçları
Atıf Sayıları
Web of Science 2
Associations of the neutrophil/lymphocyte ratio, monocyte/ lymphocyte ratio, and platelet/lymphocyte ratio with COVID-19 disease severity in patients with neurological symptoms: A cross-sectional monocentric study

Paylaş

İletişim
  • Kırşehir Ahi Evran Üniversitesi Bağbaşı Yerleşkesi, 40100, KIRŞEHİR \ TÜRKİYE
  • unis@ahievran.edu.tr
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