Analysing the diversity of the caprine melanocortin 1 receptor MC1R in goats with distinct geographic origins
Yazarlar (19)
Doç. Dr. Koray KIRIKÇI
Kırşehir Ahi Evran Üniversitesi, Türkiye
Antonia Noce
Universitat Autònoma De Barcelona, İspanya
Ali Zidi
Universitat Autònoma De Barcelona, İspanya
Juan Manuel Serradilla
Universidad De Córdoba, İspanya
Juan Carrizosa
Instituto Murciano De Investigacion Y Desarrollo Agrario Y Alimentario, İspanya
Baltasar Urrutia
Instituto Murciano De Investigacion Y Desarrollo Agrario Y Alimentario, İspanya
Fabio Pilla
Università Degli Studi Del Molise, İtalya
Mariasilvia D'andrea
Università Degli Studi Del Molise, İtalya
Juan Capote
Instituto Canario De Investigaciones Agrarias, İspanya
Iosif Bizelis
Agricultural University Of Athens, Yunanistan
Valentin Balteanu
Universitatea De Stiinte Agricole Si Medicina Veterinara Din Cluj-Napoca, Romanya
Taina Figueiredo Cardoso
Universitat Autònoma De Barcelona, İspanya
Shahin Eghbalsaied
Islamic Azad University, Isfahan Branch, İran
Agueda Pons
Unitat De Races Autòctones, İspanya
Luz Ángela Álvarez
Universidad Nacional De Colombia - Sede Palmira, Kolombiya
Michele Pazzola
Università Degli Studi Di Sassari, İtalya
Giuseppe Massimo Vacca
Università Degli Studi Di Sassari, İtalya
Gabriela Obexer-Ruff
University Hospital Bern, İsviçre
Marcel Amills
Universitat Autònoma De Barcelona, İspanya
| Makale Türü | Diğer (Teknik, not, yorum, vaka takdimi, editöre mektup, özet, kitap krıtiği, araştırma notu, bilirkişi raporu ve benzeri) (SCI, SSCI, AHCI, SCI-Exp dergilerinde yayınlanan teknik not, editöre mektup, tartışma, vaka takdimi ve özet türünden makale) | ||
| Dergi Adı | Small Ruminant Research | ||
| Dergi ISSN | 0921-4488 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 12-2016 |
| Cilt / Sayı / Sayfa | 145 / 1 / 7–11 | DOI | 10.1016/j.smallrumres.2016.10.010 |
| Makale Linki | http://linkinghub.elsevier.com/retrieve/pii/S0921448816302772 | ||
| Özet |
| In humans, the variability of the melanocortin 1 receptor (MC1R) gene has been associated with geography, being mainly determined by the amount of exposure to sunlight. Studies performed in pigs have also evidenced the existence of a geographic component in the distribution of MC1R haplotypes, probably as a consequence of an ancient split between Asian and European wild boars. Herewith, we have partially resequenced the caprine MC1R coding region in 58 goats from distinct geographic locations i.e. Colombia, Italy, Spain, France, Greece, Romania, Iran and Africa. The resulting dataset was merged with 39 previously published caprine MC1R sequences and a median joining network was built. This phylogenetic analysis did not yield any evidence of a relationship between geography and the clustering of caprine MC1R sequences, a result that was confirmed by performing a Mantel test with a previously published dataset of nine goat breeds (N = 319) with available MC1R genotypes. The majority of caprine MC1R variation was non-synonymous (c.676A > G, c.748G > T, c.764G > A and c.801C > G) and predicted to have functional effects. An analysis of goat MC1R sequences with the PAML 4 software provided evidence that two SNPs (c.764G > A and c.801C > G) might evolve under positive selection. The apparent lack of any link between caprine MC1R variation and geography might be explained by a complex array of factors including artificial selection for pigmentation phenotypes and recent divergence amongst goat breeds. |
| Anahtar Kelimeler |
| Coat color | Goat | Pigmentation | Positive selection |
Science Direct
Analysing the diversity of the caprine melanocortin 1 receptor MC1R in goats with distinct geographic origins
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 4 |
| SCOPUS | 4 |
| Google Scholar | 6 |