| Yazarlar |
Koray KIRIKÇI
Ahi Evran Üniversitesi, Türkiye |
Antonia Noce
|
|
Ali Zidi
|
|
Juan Manuel Serradilla
|
|
Juan Carrizosa
|
|
Baltasar Urrutia
|
|
Fabio Pilla
|
|
Mariasilva Dandrea
|
|
Juan Capote
|
|
Losif Bizelis
|
|
Valentin Balteanu
|
|
Taine Cardosa Figueriredo
|
|
Shahin Eghbalsaied
|
|
Agueda Pons
|
|
Luz Alvarez Angela
|
|
Michele Pazzola
|
|
Vacca Giuseppe Massimo
|
|
Gabriela Obexerruff
|
|
Marcel Amills
|
| Özet |
| In humans, the variability of the melanocortin 1 receptor (MC1R) gene has been associated with geography, being mainly determined by the amount of exposure to sunlight. Studies performed in pigs have also evidenced the existence of a geographic component in the distribution of MC1R haplotypes, probably as a consequence of an ancient split between Asian and European wild boars. Herewith, we have partially resequenced the caprine MC1R coding region in 58 goats from distinct geographic locations i.e. Colombia, Italy, Spain, France, Greece, Romania, Iran and Africa. The resulting dataset was merged with 39 previously published caprine MC1R sequences and a median joining network was built. This phylogenetic analysis did not yield any evidence of a relationship between geography and the clustering of caprine MC1R sequences, a result that was confirmed by performing a Mantel test with a previously published dataset of nine goat breeds (N = 319) with available MC1R genotypes. The majority of caprine MC1R variation was non-synonymous (c.676A > G, c.748G > T, c.764G > A and c.801C > G) and predicted to have functional effects. An analysis of goat MC1R sequences with the PAML 4 software provided evidence that two SNPs (c.764G > A and c.801C > G) might evolve under positive selection. The apparent lack of any link between caprine MC1R variation and geography might be explained by a complex array of factors including artificial selection for pigmentation phenotypes and recent divergence amongst goat breeds. |
| Anahtar Kelimeler |
| Coat color | Goat | Pigmentation | Positive selection |
| Makale Türü | Diğer (Teknik, not, yorum, vaka takdimi, editöre mektup, özet, kitap krıtiği, araştırma notu, bilirkişi raporu ve benzeri) |
| Makale Alt Türü | SCI, SSCI, AHCI, SCI-Exp dergilerinde yayımlanan teknik not, editöre mektup, tartışma, vaka takdimi ve özet türünden makale |
| Dergi Adı | Small Ruminant Research |
| Dergi ISSN | 0921-4488 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 12-2016 |
| Cilt No | 145 |
| Sayı | 1 |
| Sayfalar | 7 / 11 |
| Doi Numarası | 10.1016/j.smallrumres.2016.10.010 |
| Makale Linki | http://linkinghub.elsevier.com/retrieve/pii/S0921448816302772 |
| Atıf Sayıları | |
| SCOPUS | 4 |
| Google Scholar | 7 |
