| Yazarlar (5) |
Özden Özdemir
|
|
Oya Tekeli
Ankara Üniversitesi, Türkiye |
Prof. Dr. Kemal ÖRNEK
Kırıkkale Üniversitesi, Türkiye |
|
Arslanpençe Ayşe
|
|
Fatime Nilüfer Yalçındağ
Ankara Üniversitesi, Türkiye |
| Özet |
| Aim To investigate and compare the surgical outcomes of limbal autograft and limbal allograft transplantations in patients with corneal burns. Methods In total, 20 patients (n = 22 eyes) with chemical burn and two patients ( n = 2 eyes) with thermal burn were included in this study. Limbal autograft or limbal allograft transplantation surgery was performed in all patients. HLA-typing was tested before allograft surgeries. Limbal allografting was performed in all eyes using donor tissue from live relatives. Systemic cyclosporine A was administered for immunosuppression. Results The corneal surface was successfully reconstructed in all eyes (100%) after limbal autografting, two eyes required additional amniotic membrane transplantation and one eye required allografting. The mean follow-up period for limbal autografts was 13.9 +/- 7.0 months. Limbal allografting failed to reduce corneal vascularity and opacification in five (55.6%) eyes and was successful only in four (44.4%) eyes ( mean follow-up 16.2 +/- 11.2 months) ( P = 0.002). In all, 15 eyes undergoing limbal autografting completed reepithelialization of the cornea at a mean of 35.6 +/- 60.2 days. The mean epithelial healing time in nine eyes undergoing limbal allografting was 13.0 +/- 7.3 days ( P = 0.525). After limbal autografting, functional vision (greater than or equal to1/10) was attained in 12 (80%) eyes. Only one eye (11.1%) achieved functional vision after limbal allografting ( P = 0.036). Penetrating keratoplasty was performed in three patients following limbal allografting. No cyclosporine-associated side effects were observed. Conclusions Limbal autograft transplantation is an effective and safe procedure for unilateral corneal burns. It seems that limbal allograft transplantation is better combined with penetrating keratoplasty for a better visual outcome and higher graft survival rate. Systemic immunosuppression seems to be necessary for limbal allografts even in the presence of HLA-matched donor tissues. |
| Anahtar Kelimeler |
| limbal autografting | limbal allografting | chemical burn | thermal burn |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | EYE |
| Dergi ISSN | 0950-222X Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI |
| Makale Dili | İngilizce |
| Basım Tarihi | 03-2004 |
| Cilt No | 18 |
| Sayı | 3 |
| Sayfalar | 241 / 248 |
| Doi Numarası | 10.1038/sj.eye.6700640 |
| Atıf Sayıları | |
| WoS | 42 |
| SCOPUS | 47 |
| Google Scholar | 68 |
