May nitric oxide molecule have a role in the pathogenesis of human cataract
Yazarlar (3)
Prof. Dr. Kemal ÖRNEK Ankara Üniversitesi, Türkiye
Fatih Karel
Ankara Üniversitesi, Türkiye
Ankara Üniversitesi, Türkiye
Zeliha Büyükbingöl Ankara Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Experimental Eye Research | ||
| Dergi ISSN | 0014-4835 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2003 |
| Kabul Tarihi | 12-04-2026 | Yayınlanma Tarihi | – |
| Cilt / Sayı / Sayfa | 76 / 1 / 23–27 | DOI | 10.1016/S0014-4835(02)00268-3 |
| Özet |
| Recent studies have shown that nitric oxide molecule may have a role in the development of cataract. In this study, we measured the levels of a nitric oxide metabolite (nitrite) in the cataractous and normal human lenses. A modified Griess assay was used to determine the nitrite levels in the lenses as a measure of nitric oxide, based on the spectrophotometric method. Nitrite was detected in 26 (44·1%) cataractous lenses and was found below the detection limit in 33 (55·9%) cataractous lenses. Mean nitrite levels in cataractous lenses (2·77±5·26nmol/100mg) was found higher than the normal lenses (0·77±0·79nmol/100mg) but this increase was not statistically significant. Comparison of nitrite levels among lenses with various types of cataracts revealed higher levels in lenses with posterior subcapsular cataracts. Hypertensive patients had also significantly higher nitrite levels in their cataractous lenses. The … |
| Anahtar Kelimeler |
| Griess assay | Human cataract | Human lens | Hypertension | Nitric oxide | Nitrite | Posterior subcapsular cataract |
Science Direct
May nitric oxide molecule have a role in the pathogenesis of human cataract
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 76 |
| Scopus | 6 |
| Web of Science | 54 |