img
img
Optical coherence tomography and visual field findings in patients with Friedreich ataxia      
Yazarlar (4)
Ersel Dağ
Kırıkkale Üniversitesi, Türkiye
Nurgül Örnek
Kırıkkale Üniversitesi, Türkiye
Prof. Dr. Kemal ÖRNEK Prof. Dr. Kemal ÖRNEK
Kırıkkale Üniversitesi, Türkiye
Erbahçeci İnci Elif
Devamını Göster
Özet
Background: To investigate the optical coherence tomography (OCT) and visual field findings in Friedreich ataxia (FRDA).
Methods: Ten eyes of 10 patients with genetically confirmed FRDA were included in this study. Twenty-two eyes of 22 age- and sex-matched volunteers served as controls. All eyes were examined with spectral domain OCT (Retinascan Advanced RS-3000; NIDEK) and Humphrey Field Analyzer (HFA II 750; Zeiss-Humphrey Systems).
Results: OCT measurements of the average peripapillary retinal nerve fiber layer (RNFL) thickness, average peripapillary retinal thickness (RT), and foveal RT showed a statistically significant reduction in patients with FRDA (P, 0.0001). There was no statistically significant difference in choroidal thickness. OCT measurements of horizontal cup-to-disc (C/D) ratio, vertical C/D ratio, and average cup area were significantly increased in patients with FRDA. Visual acuity was significantly correlated with age at onset (P = 0.021) and average RNFL value (P = 0.045). There was a significant correlation between foveal thickness and disease duration (P = 0.014). Mean RNFL thickness was significantly correlated with the severity of neurological involvement (P = 0.039). Visual field testing (VFT) revealed a generalized reduction of sensitivity in the patients.
Conclusion: Patients with FRDA may have a measurable degree of retinal thinning as determined by OCT and a generalized reduction of sensitivity in VFT. Combining structural and functional findings may be used in the follow-up of patients with FRDA. (C) 2013 by North American Neuro-Ophthalmology Society
Anahtar Kelimeler
Makale Türü Özgün Makale
Makale Alt Türü SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale
Dergi Adı JOURNAL OF NEURO-OPHTHALMOLOGY
Dergi ISSN 1070-8022 Wos Dergi Scopus Dergi
Dergi Tarandığı Indeksler SCI
Makale Dili İngilizce
Basım Tarihi 06-2014
Cilt No 34
Sayı 2
Sayfalar 118 / 121
Doi Numarası 10.1097/WNO.0000000000000068