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Corneal sensitivity and tear function in neurodegenerative diseases     
Yazarlar
Nurgül Örnek
Kırıkkale Üniversitesi, Türkiye
Ersel Dağ
Kırıkkale Üniversitesi, Türkiye
Prof. Dr. Kemal ÖRNEK
Kırıkkale Üniversitesi, Türkiye
Özet
Purpose: To measure corneal sensitivity and tear function in neurodegenerative diseases (NDs) and to compare them with age and sex-matched controls.
Methods: Twenty patients with Alzheimer's disease (AD), 20 patients with multiple sclerosis (MS), 30 patients with Parkinson's disease (PD), 10 patients with Friedreich's ataxia (FA) and 21 patients with epilepsy (EP) who were recruited from the Kirikkale University Neurology Department during 2012 were included in this prospective study. Five groups of age and sex-matched subjects were selected as controls. Corneal sensitivity was measured using a Cochet-Bonnet esthesiometer. Tear function tests included tear break-up time (TBUT) and Schirmer's 1 tests.
Results: Compared to their controls, mean corneal sensitivity was significantly reduced in AD, MS, PD and EP patients (all p<0.05), mean TBUT level was significantly shorter in patients with AD and MS (all p<0.05) and mean Schirmer's 1 test score was significantly lower in EP patients (p<0.05). When all groups were compared with each other, reduction of mean corneal sensitivity in AD and PD groups were significantly more than in FA and MS groups (overall p = 0.034). Mean TBUT levels in AD, MS and PD groups were significantly shorter than in FA and EP groups (overall p = 0.001). Mean Schirmer's 1 test scores in AD and PD groups were significantly lower than in MS, FA and EP groups (overall p = 0.040).
Conclusions: Neurodegenerative diseases may be associated with reduced corneal sensitivity and abnormal tear function.
Anahtar Kelimeler
Corneal sensitivity | neurodegenerative diseases | tear function
Makale Türü Özgün Makale
Makale Alt Türü SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale
Dergi Adı CURRENT EYE RESEARCH
Dergi ISSN 0271-3683
Dergi Tarandığı Indeksler SCI-Expanded
Makale Dili İngilizce
Basım Tarihi 04-2015
Cilt No 40
Sayı 4
Sayfalar 423 / 428
Doi Numarası 10.3109/02713683.2014.930154
BM Sürdürülebilir Kalkınma Amaçları
Atıf Sayıları
WoS 42
Google Scholar 66
Corneal sensitivity and tear function in neurodegenerative diseases

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