| Yazarlar (5) |
Nurgül Örnek
Kırıkkale Üniversitesi, Türkiye |
Prof. Dr. Kemal ÖRNEK
Kırıkkale Üniversitesi, Türkiye |
|
Süleyman Aydın
Fırat Üniversitesi, Türkiye |
|
Musa Yılmaz
|
|
Yaşar Ölmez
Kırıkkale Üniversitesi, Türkiye |
| Özet |
| AIM: To investigate the serum levels of vascular endothelial growth factor receptor-2 (VEGFR-2) and adropin in age-related macular degeneration (AMD) patients. METHODS: Ninety-eight AMD patients were included in the study. Seventy-eight age - and sex-matched healthy volunteers were recruited as the control group. Fundus florescein angiography and optical coherence tomography were performed to assess the posterior segment details. Serum VEGFR-2 and adropin levels were measured using enzyme-linked immunosorbent assays and compared between the study groups. RESULTS: AMD group had significantly increased fovea! retinal thickness, serum LDL and HDL levels and significantly decreased subfoveal choroidal thickness (P = 0.01, 0.047, 0.025 and <0.001, respectively). Serum VEGFR-2 level revealed a significant decrease in AMD patients compared to controls (26.48 +/- 6.44 vs 30.42 +/- 7.92 ng/mL, P<0.001). There was an insignificant increase in serum adropin level in AMD patients (6.17 +/- 1-3.19 vs 5.79 +/- 2.71 ng/mL, P=0.4). Serum level of VEGFR-2 in AMD patients had a significant negative correlation with fovea! retinal thickness (r=-0.226, P=0.025) and a significant positive correlation with subfoveal choroidal thickness (r=0.2, P=0.048). CONCLUSION: The current study demonstrated that the decreased serum VEGFR-2 level may be considered in the development of AMD. Adropin does not seem to play a role in the pathogenesis of AMD. |
| Anahtar Kelimeler |
| vascular endothelial growth factor receptor-2 | adropin | age-related macular degeneration |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | INTERNATIONAL JOURNAL OF OPHTHALMOLOGY |
| Dergi ISSN | 2222-3959 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 04-2016 |
| Cilt No | 9 |
| Sayı | 4 |
| Sayfalar | 556 / 560 |
| Doi Numarası | 10.18240/ijo.2016.04.13 |
| Atıf Sayıları | |
| WoS | 8 |
| SCOPUS | 6 |
| Google Scholar | 11 |
