Relation Of Gene And Some Biochemical Parameters In Diabetic Patients With Osteoarthritis
Yazarlar (3)
İltifat Abdulrezzaq Jawad Alsahlanee
Dr. Öğr. Üyesi İsmail BAYRAM Kırşehir Ahi Evran Üniversitesi, Türkiye
Lames Majid Hameed Al-Janabi
| Makale Türü | Özgün Makale (SCOPUS dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Natural Volatiles& Essentiol Oils | ||
| Dergi ISSN | 2148-9637 | ||
| Dergi Tarandığı Indeksler | Scopus | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2022 |
| Cilt / Sayı / Sayfa | 9 / 1 / 1321–1330 | DOI | – |
| Makale Linki | https://www.nveo.org/index.php/journal/article/view/4740 | ||
| UAK Araştırma Alanları |
Genetik
Moleküler Biyoloji
|
||
| Özet |
| Matrilin-3 is a protein found in the extracellular matrix that is not composed of collagen. The MATN3 gene is found on the short arm of chromosome 2 region 2p24-p23. Matn3 is found at lower levels in mature articular cartilage (AC), but its expression is induced through (OA), This pattern of expression indicates that Matrilin-3 has a role in the etiology of osteoarthritis. Some studies have found that mutations in the MATN3 gene area are a risk factor for OA. this study aimed to examine the association of the Matn3 (rs77245812) SNP(C/T) gene polymorphism as a risk factor for osteoarthritis. genotyping of the SNP(C/T) was performed in 50 type2 diabetes with osteoarthritis, 50 osteoarthritis, and 50 control subjects. Genomic DNA was isolated from venous blood samples, quantified, and subjected to conventional PCR. statistical analysis showed no association found between Matn3 (rs77245812) and the risk … |
| Anahtar Kelimeler |
