Synthesis of Some Novel Isoxazolidine Derivatives via 1,3-Dipolar Cycloaddition and Their Biological Evaluation
Yazarlar (5)
Gazi Üniversitesi, Türkiye
Gazi Üniversitesi, Türkiye
Gazi Üniversitesi, Türkiye
Prof. Dr. Hatice ÖĞÜTCÜ
Kırşehir Ahi Evran Üniversitesi, Türkiye
Zonguldak Bülent Ecevit Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(ESCI dergilerinde yayınlanan tam makale)
|
||
| Dergi Adı | Gazi University Journal of Science | ||
| Dergi ISSN | 2147-1762 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | TR DİZİN | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2019 |
| Cilt / Sayı / Sayfa | 32 / 1 / 78–89 | DOI | – |
| Özet |
| A series of novel substituted isoxazolidine derivatives were synthesized by 1,3-dipolarcycloaddition reactions of α-aryl-N-methyl nitrones with diethyl maleate. The structures of thesynthesized compounds were characterized using spectroscopic methods. All the synthesizedcompounds were screened for their antibacterial activities against Gram-positive and Gramnegativebacteria and for their antifungal activities against a yeast strain. The results show that allthe synthesized compounds displayed significant activity against S. epidermidis, M. luteus, B.cereus, B. abortus and C. albicans when compared to standard drugs. |
| Anahtar Kelimeler |
| Isoxazolidine | Nitrone | 1,3-Dipolar cycloaddition reaction | Antimicrobial activity |
