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Synthesis of Some Novel Isoxazolidine Derivatives via 1,3-Dipolar Cycloaddition and Their Biological Evaluation     
Yazarlar
Volkan Yanmaz
Ali Dişli
Gazi Üniversitesi, Türkiye
Serkan Yavuz
Gazi Üniversitesi, Türkiye
Prof. Dr. Hatice ÖĞÜTCÜ Prof. Dr. Hatice ÖĞÜTCÜ
Kırşehir Ahi Evran Üniversitesi, Türkiye
Gülay Dilek
Zonguldak Bülent Ecevit Üniversitesi, Türkiye
Özet
A series of novel substituted isoxazolidine derivatives were synthesized by 1,3-dipolarcycloaddition reactions of α-aryl-N-methyl nitrones with diethyl maleate. The structures of thesynthesized compounds were characterized using spectroscopic methods. All the synthesizedcompounds were screened for their antibacterial activities against Gram-positive and Gramnegativebacteria and for their antifungal activities against a yeast strain. The results show that allthe synthesized compounds displayed significant activity against S. epidermidis, M. luteus, B.cereus, B. abortus and C. albicans when compared to standard drugs.
Anahtar Kelimeler
Isoxazolidine | Nitrone | 1,3-Dipolar cycloaddition reaction | Antimicrobial activity
Makale Türü Özgün Makale
Makale Alt Türü ESCI dergilerinde yayımlanan tam makale
Dergi Adı GAZI UNIVERSITY JOURNAL OF SCIENCE
Dergi ISSN 2147-1762
Dergi Tarandığı Indeksler TR DİZİN
Makale Dili Türkçe
Basım Tarihi 01-2019
Cilt No 32
Sayı 1
Sayfalar 78 / 89
BM Sürdürülebilir Kalkınma Amaçları
Atıf Sayıları
WoS 4

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