Synthesis and Antibacterial Activity of New Chiral Aminoalcohol and Benzimidazole Hybrids
Yazarlar (6)
Kirsehir Ahi Evran University
Doç. Dr. Turgay TUNÇ
Kırşehir Ahi Evran Üniversitesi, Türkiye
Prof. Dr. Hatice ÖĞÜTCÜ
Kırşehir Ahi Evran Üniversitesi, Türkiye
Marmara Üniversitesi, Türkiye
Prof. Dr. Aslıhan GÜNEL
Kırşehir Ahi Evran Üniversitesi, Türkiye
Prof. Dr. Nadir DEMİREL
Kırşehir Ahi Evran Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | CHEMISTRYSELECT | ||
| Dergi ISSN | 2365-6549 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 04-2020 |
| Cilt / Sayı / Sayfa | 5 / 15 / 4650–4654 | DOI | 10.1002/slct.202000355 |
| Makale Linki | [{"content-version":"vor","content-type":"application/pdf","intended-application":"text-mining","URL":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fslct.202000355"},{"content-version":"vor","content-type":"application/pdf","intended- | ||
| Özet |
| New chiral aminoalcohol-benzimidazole hybrids have been synthesized from commercially available aminoalcohols [S(+)-Phenylglycinol, S(-)- Phenylalaninol and S(+)- Leuicinol] and 2-(chloromethyl)-N-tosyl-1-H-benzimidazole. The synthesized compound were characterized by IR, NMR, and LC-MS analysis. The antibacterial properties of aminoalcohol-benzimidazole hybrid molecules 4 a, 4 b, and 4 c were investigated against both gram (+ve) and gram (-ve) bacterial pathogens by the well-diffusion method using several standarts. The cell-based biological experiment was consistent with in silico studies. Furthermore, in silico studies revealed that all synthesized compounds could be suggested as potential drugs for inhibition of both peptide deformylase for bacteria and sterol 14 alpha-demethylase for yeast. |
| Anahtar Kelimeler |
| Benzimidazole | Antibacterial Agent | Aminoalcohol | PDF inhibitor | Molecular docking |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 9 |