| Yazarlar (6) |
Ünal Bakal
Fırat Üniversitesi, Türkiye |
|
Mehmet Saraç
Fırat Üniversitesi, Türkiye |
Prof. Dr. Harun ÇİFTÇİ
Kırşehir Ahi Evran Üniversitesi, Türkiye |
|
Tugay Tartar
Fırat Üniversitesi, Türkiye |
|
Ahmet Kazez
Fırat Üniversitesi, Türkiye |
|
Süleyman Aydın
|
| Özet |
| Objective Appetite loss is seen in 90% to 95% of patients with acute appendicitis; however, the cause of this symptom remains unknown. This study is performed to determine whether changes in the blood levels of two anorexigenic hormones, leptin and NUCB2/nesfatin-1, can help to diagnose acute appendicitis in children and whether these two parameters can distinguish acute appendicitis from abdominal pain. Methods Sixty children with comparable ages and body mass indices are divided into three groups of 20 children each: those with acute appendicitis, those with abdominal pain, and controls. The blood sample with acute appendicitis is taken preoperatively (T1), and subsequent samples are taken 24 hrs postoperatively (T2) and 3 days postoperatively (T3). The blood sample with abdominal pain subjects is also taken in the corresponding times with those with acute appendicitis while blood sample from controls is only taken in the T1 corresponding time. Leptin and NUCB2/nesfatin-1 levels are measured by enzyme-linked immunosorbent assay. Results The serum leptin levels are significantly higher preoperatively than postoperatively in all three groups. The NUCB2/nesfatin-1 levels at T1 in acute appendicitis are significantly higher than those at T2 in all three groups, but are restored at T3 to levels similar to those of controls. Neutrophil percentage has a sensitivity of 100%, and specificity of 76.32%, NUCB2/nesfatin-1 level has a sensitivity of 47% and specificity of 95%, and the leptin level has a sensitivity of 64% and specificity of 51% in the diagnosis of acute appendicitis. Conclusions High preoperative leptin and NUCB2/nesfatin-1 … |
| Anahtar Kelimeler |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SCOPUS dergilerinde yayınlanan tam makale |
| Dergi Adı | International Journal of Clinical Medicine |
| Dergi ISSN | 2158-284X |
| Dergi Tarandığı Indeksler | Scopus |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2015 |
| Cilt No | 6 |
| Sayı | 12 |
| Sayfalar | 919 / 927 |
| Doi Numarası | 10.4236/ijcm.2015.612120 |
| Makale Linki | http://www.scirp.org/journal/PaperDownload.aspx?DOI=10.4236/ijcm.2015.612120 |
| Atıf Sayıları | |
| Google Scholar | 4 |
