| Yazarlar (7) |
Prof. Dr. Harun ÇİFTÇİ
Kırşehir Ahi Evran Üniversitesi, Türkiye |
Ahmet Özkaya
Adıyaman Üniversitesi, Türkiye |
|
Alpaslan Dayangaç
Kırşehir Ahi Evran Üniversitesi, Türkiye |
|
Ali Ölçücü
Fırat Üniversitesi, Türkiye |
|
Sait Çelik
Uşak Üniversitesi, Türkiye |
|
Zafer Şahin
Firat Üniversitesi, Türkiye |
|
Sema Ateş
Firat Üniversitesi, Türkiye |
| Özet |
| The oxidative stress, depending on many factors in the etiology of developing cancer caused by reactive oxygen species, plays an important role. In our study, 7, 12-dimethylbenz-[a]anthracene (DMBA) was applied in Guinea Pigs, the alpha lipoic acid (α-LA) has antioxidant properties was investigated protective role against to levels of macro and trace elements in brain. In experiments; totally 24 adult male Guinea Pigs were randomly divided into 4 equal groups (control, DMBA, α-LA and DMBA+α-LA) containing same numbers. As a result of the analysis in Guinea Pigs brain with the aid of ICP-AES; it was found that the level of calcium from macro elements in DMBA group increased according to control group (P<0.01) and decreased in DMBA+α-LA group (P<0.01), that was in the same levels with control group. Magnesium decreased in DMBA group according to control group (P<0.01) and DMBA+α-LA group and increased in close level of control group. Regarding trace elements, it was seemed that copper levels compared with the control group decreased in DMBA group (P<0.01) and DMBA+α-LA group, it was same level with control group. It was observed that the level zinc decreased according to control group in DMBA group (P<0.01) and increased in DMBA+α-LA group (P<0.01). In addition, it was obtained that levels of iron and manganese in between groups were not significant (P>0.05). As a result, it can be said that from the point of macro and trace elements, the lipoic acid (α-LA) was indicated neuroprotective effect for protection of important organs such as brain from the oxidative stress. |
| Anahtar Kelimeler |
| DMBA | 7,12-dimetilbenz-[a]antrasen | alpha-Lipoic acid | Trace Element | ICP-AES | Brain | Guinea pig |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | KAFKAS UNIVERSITESI VETERINER FAKULTESI DERGISI |
| Dergi ISSN | 1300-6045 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2009 |
| Cilt No | 15 |
| Sayı | 4 |
| Sayfalar | 569 / 573 |
| Doi Numarası | 10.9775/kvfd.2009.067-a |
| Atıf Sayıları | |
| WoS | 7 |
| SCOPUS | 7 |
| Google Scholar | 11 |
