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Prognostic value of thiol/disulfide homeostasis in symptomatic patients with heart failure    
Yazarlar
 Hacı Mehmet ÇALIŞKAN Hacı Mehmet ÇALIŞKAN
Kırşehir Ahi Evran Üniversitesi, Türkiye
Serkan Sivri
Türkiye
 Erdoğan SÖKMEN Erdoğan SÖKMEN
Kırşehir Ahi Evran Üniversitesi, Türkiye
Mustafa Çelik
Türkiye
 Bilal İLANBEY Bilal İLANBEY
Türkiye
Sinan Cemgil Özbek
Türkiye
Burak Çelik
Özet
We aimed to examine the role of thiol/disulphide homeostasis (TDH) in heart failure and its stages and the prognosis of heart failure. A total of 140 subjects were included in the study. Total and native thiol levels were higher in the control group compared to the patient groups (p < .001). While the average disulphide/total thiol ratio was similar in groups 1 and 2, it was found to be significantly lower in the control group compared to other groups and significantly higher in group 3 compared to other groups (p < .05). Mean native thiol and total thiol levels were found lower in patients with mortality compared to surviving patients (p < .001). In ROC curve analysis, it was determined that the total thiol level had 81.8% sensitivity and 83.1% specificity, and native thiol level had 81.8% sensitivity and 84.3% specificity. We found that TDH was impaired in favour of disulphide in cases of heart failure.
Anahtar Kelimeler
Heart failure | left ventricular ejection fraction | mortality | thiol | disulphide homeostasis
Makale Türü Özgün Makale
Makale Alt Türü SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale
Dergi Adı ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
Dergi ISSN 1381-3455
Dergi Tarandığı Indeksler SCI-Expanded
Dergi Grubu Q1
Makale Dili İngilizce
Basım Tarihi 09-2021
Cilt No 127
Sayı 5
Sayfalar 462 / 467
Doi Numarası 10.1080/13813455.2020.1773505
Makale Linki https://www.tandfonline.com/doi/full/10.1080/13813455.2020.1773505