Prognostic value of thiol/disulfide homeostasis in symptomatic patients with heart failure
Yazarlar (7)
Doç. Dr. Hacı Mehmet ÇALIŞKAN
Kırşehir Ahi Evran Üniversitesi, Türkiye
Kirsehir Ahi Evran University, Türkiye
Prof. Dr. Erdoğan SÖKMEN
Kırşehir Ahi Evran Üniversitesi, Türkiye
Kirsehir Ahi Evran University, Türkiye
Doç. Dr. Bilal İLANBEY
Kırşehir Ahi Evran Üniversitesi, Türkiye
Kirsehir Ahi Evran University, Türkiye
Kirsehir Ahi Evran University
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY (Q1) | ||
| Dergi ISSN | 1381-3455 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 09-2021 |
| Cilt / Sayı / Sayfa | 127 / 5 / 462–467 | DOI | 10.1080/13813455.2020.1773505 |
| Makale Linki | https://www.tandfonline.com/doi/full/10.1080/13813455.2020.1773505 | ||
| Özet |
| We aimed to examine the role of thiol/disulphide homeostasis (TDH) in heart failure and its stages and the prognosis of heart failure. A total of 140 subjects were included in the study. Total and native thiol levels were higher in the control group compared to the patient groups (p < .001). While the average disulphide/total thiol ratio was similar in groups 1 and 2, it was found to be significantly lower in the control group compared to other groups and significantly higher in group 3 compared to other groups (p < .05). Mean native thiol and total thiol levels were found lower in patients with mortality compared to surviving patients (p < .001). In ROC curve analysis, it was determined that the total thiol level had 81.8% sensitivity and 83.1% specificity, and native thiol level had 81.8% sensitivity and 84.3% specificity. We found that TDH was impaired in favour of disulphide in cases of heart failure. |
| Anahtar Kelimeler |
| Heart failure | left ventricular ejection fraction | mortality | thiol | disulphide homeostasis |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 2 |