| Yazarlar |
Dr. Öğr. Üyesi Habibe Sema ARSLAN
Türkiye |
Ayşe Feyda Nursal
Hitit Üniversitesi, Türkiye |
|
Ahmet İnanır
Türkiye |
|
Nevin Karakuş
Türkiye |
|
Serbülent Yiğit
Türkiye |
| Özet |
| Background: Fibromyalgia syndrome (FMS) is characterized by widespread musculoskeletal pain. It is more common in women than in men, and sex hormones may play a role in this predominance. Therefore, this research investigated the clinical findings among Turkish females and whether Estrogen-alpha (ESR1) gene variants are associated with FMS. Methods: A total of 219 individuals were enrolled in this study. ESR1 variants (Pvull/XbaI) were genotyped using PCR-RFLP methods. The results of the analyses were evaluated for statistical significance. Results: There was a significant association between the ESR1 PvuII and FMS risk among Turkish women. The ESR1 PvuII CC genotype and C allele were higher in the patients than those in the controls (p=0.021, p=0.007, respectively). A more statistically significant association was observed between the patients and the controls in terms of TT genotype vs. TC+CC genotypes (p=0.022). Also, there was a statistically significant association between the patients and the controls in terms of TT+TC genotype vs. CC genotypes (p =0.028). There was no significant association between patients and the control group concerning the genotype distribution and allele frequencies of ESR1 XbaI (p>0.05). Headache was seen more frequently in the XbaI GA genotype (p =0.025), while XbaI AA genotype was associated with dysmenorrhea in patients with FMS (p=0.041). Conclusion: Our results indicate that ESR1 PvuII/XbaI variants are possibly effective in the development of FMS and some clinical features. |
| Anahtar Kelimeler |
| Fibromiyalgia syndrome | estrogen receptor-alpha | Pvull | XbaI | variant | women |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS |
| Dergi ISSN | 1871-5303 |
| Dergi Tarandığı Indeksler | SCI |
| Makale Dili | Türkçe |
| Basım Tarihi | 01-2021 |
| Cilt No | 21 |
| Sayı | 7 |
| Sayfalar | 1326 / 1332 |
| Doi Numarası | 10.2174/1871530320666200910110915 |
| Makale Linki | https://pubmed.ncbi.nlm.nih.gov/32914729/ |
| Atıf Sayıları | |
| WoS | 3 |
